S-adenosyl-L-methionine

SAMe/Nutrient Depletions:

  • CholesterolCholesterol: In a human study designed to examine the potential negative effects of SAMe on homocysteine levels, a small but statistically significant decrease in total cholesterol occurred (186). A reduction in cholesterol levels occurred in some subjects in a separate study (179).
  • GlucoseGlucose: SAMe 600mg daily given intravenously reduced blood glucose in patients with type 2 diabetes (78).