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Sodium bicarbonate
Sodium bicarbonate/Nutrient Depletion:
Calcium
Calcium: According to a systematic review, adverse effects following sodium bicarbonate administration included hypocalcemia (
106
). According to a systematic review, adverse effects specific to the use of sodium bicarbonate for urinary alkalization included severe alkalemia leading to tetany, hypokalemia, and hypocalcemia (
83
).
Phosphate
Phosphate: According to a review, use of sodium bicarbonate could contribute to hypophosphatemia (
75
).
Potassium
Potassium: According to a systematic review, adverse effects following sodium bicarbonate administration included hypokalemia (
106
). According to a systematic review, adverse effects specific to the use of sodium bicarbonate for urinary alkalization included severe alkalemia leading to tetany, hypokalemia, and hypocalcemia (
83
). According to case reports in humans, symptoms of metabolic alkalosis associated with calcium carbonate antacids and several tablespoons daily of sodium bicarbonate included dizziness and tachycardia, hypokalemia and dehydration, and loss of consciousness with shivering (
107
).
Iron
Iron: In human research, sodium bicarbonate decreased the absorption of iron (
124
).