Tin

Tin/Nutrient Depletion:

  • CopperCopper: Rats fed 200mcg/g of tin retained less copper in tissues and excreted more in feces than control rats (64). Tin deficiency in rats affects copper levels in the heart and tibia, according to a review (12).
  • DaspartateD-aspartate: Trimethyl tin inhibited the uptake and stimulated the release of D-aspartate in primary cultures of rat astrocytes (46).
  • IronIron: In rats fed moderate-to-high levels of dietary tin, depressed hematocrit, hemoglobin, and serum iron have been observed (50; 51; 52; 53; 54). Information on doses was lacking. Tin deficiency in rats affects iron levels in muscle, spleen, and kidney, according to a review (12).
  • L-glutamateL-glutamate: Trimethyl tin inhibited the uptake and stimulated the release of L-glutamate in primary cultures of rat astrocytes (46).
  • Vitamin DVitamin D: In guinea pigs, painting of tributyltin oxide on the skin induced reduction of serum 1-25-dihydroxyvitamin D (55).
  • ZincZinc: In human research, subjects fed a high-tin diet (~50mg daily, comparable to two cups of canned food) for 20 days excreted higher levels of zinc in feces and lower levels in urine than subjects fed a low-tin diet (0.11mg daily, equivalent to eating no tinned food) (54). Rats fed 200mcg/g tin of retained less zinc in tissues and excreted more in feces than control rats (64). Tin deficiency in rats affects zinc levels in the heart, according to a review (12).