Octanoic acid

Related Terms

Alpha-hydroxy caprylic acid, medium-chain fatty acid, medium chain triglyceride (MCT), monocaprylin, octanoic acid, suberic acid.

Background

Caprylic acid is an eight-carbon fatty acid naturally found in palm and coconut oil, and in the milk of humans and bovines (cows). Caprylic acid is classified as a medium-chain fatty acid and chemically known as octanoic acid. The U.S. Food and Drug Administration (FDA) has approved caprylic acid with generally recognizable as safe (GRAS) status. It is used as parenteral nutrition in patients who require nutrition supplementation, as well as in some drugs, foods, and cosmetics.
Nutritionists often recommend caprylic acid for use in treating candidiasis (yeast infection) and bacterial infections. However, there is insufficient clinical data available to support the used of caprylic acid for any claimed therapeutic uses.

Evidence Table

These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. GRADE *
These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. GRADE *


Some forms of epilepsy respond to diets that are high in fat and low in carbohydrates. Currently, the effects of caprylic acid alone to treat epilepsy in children are not well studied. Additional study is needed in this area.

 C


Some forms of epilepsy respond to diets that are high in fat and low in carbohydrates. Currently, the effects of caprylic acid alone to treat epilepsy in children are not well studied. Additional study is needed in this area.

 C
* Key to grades

A: Strong scientific evidence for this use
B: Good scientific evidence for this use
C: Unclear scientific evidence for this use
D: Fair scientific evidence for this use (it may not work)
F: Strong scientific evidence against this use (it likley does not work)
* Key to grades

A: Strong scientific evidence for this use
B: Good scientific evidence for this use
C: Unclear scientific evidence for this use
D: Fair scientific evidence for this use (it may not work)
F: Strong scientific evidence against this use (it likley does not work)

Tradition / Theory

The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.

Dosing

Adults (18 years and older)
There is no proven safe or effective dose for caprylic acid. In general, 300-1,200 milligrams daily, preferably 30 minutes before meals, has been ingested.

Safety

The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.

Interactions

Interactions with Drugs
Caprylic acid may alter the effects of drugs that are highly bound to albumin. Patients taking any medications should check the package insert, and consult with a qualified healthcare professional, including a pharmacist.
Theoretically, caprylic acid may increase susceptibility to carbaryl exposure and decrease the body's ability to clear carbaryl, a highly toxic insecticide. Caution is advised.
Indomethacin can inhibit the cardiovascular effects of octanoic acid. Patients taking cardiovascular medications should consult with a qualified healthcare professional, including a pharmacist, about interactions.
Although not well studied in humans, caprylic acid may also interact with inotropic agents, nimodipine, phenylbutazone, warfarin and non-steroidal anti-inflammatory drugs (NSAIDS).

Attribution

This information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com).

Bibliography

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