Calcium phosphate

Related Terms

Aluminum phosphate, anhydrous sodium phosphate, bone ash, bone phosphate, calcium orthophosphate, calcium phosphate, calcium phosphate dibasic anhydrous, calcium phosphate dibasic dihydrate, calcium phosphate tribasic, colestilan, dibasic potassium phosphate, dibasic sodium phosphate, dicalcium phosphate, dicalcium phosphate, dipotassium hydrogen orthophosphate, dipotassium monophosphate, dipotassium phosphate, disodium hydrogen orthophosphate, disodium hydrogen orthophosphate dodecahydrate, disodium hydrogen phosphate, disodium phosphate, elemental phosphorus, MCI-196, monobasic potassium phosphate, monobasic sodium phosphate, neutral calcium phosphate, phosphate of soda, phosphatidylcholine, phosphatidylserine, potassium acid phosphate, potassium biphosphate, potassium dihydrogen orthophosphate, potassium phosphate, precipitated calcium phosphate, sevelamer (Renagel?), sodium orthophosphate, sodium phosphate, tertiary calcium phosphate, tribasic sodium phosphate, tricalcium phosphate, whitlockite.
Note: The term "phosphates" in this monograph refers to anhydrous sodium acid phosphate, dibasic sodium phosphate, dipotassium phosphate anhydrous, monobasic potassium acid phosphate, monobasic sodium phosphate, phosphorus, potassium phosphate, sodium biphosphate, and sodium phosphate. Phosphate salts should not be confused with toxic substances such as organophosphates, or with tribasic sodium phosphates and tribasic potassium phosphates, which are strongly alkaline.

Background

Phosphorus is a mineral found in many foods, such as milk, cheese, grains, dried beans, peas, colas, nuts, and peanut butter. Phosphate is the most common form of phosphorus. In the body, phosphate is the most abundant intracellular anion. It is critical for energy storage and metabolism, the utilization of many B-complex vitamins, the buffering of body fluids, kidney excretion of hydrogen ions, proper muscle and nerve function, and maintaining calcium balance. Phosphorus is vital to the formation of bones and teeth, and healthy bones and soft tissues require calcium and phosphorus to grow and develop throughout life. Inadequate intake of dietary phosphate can lead to hypophosphatemia (low levels of phosphate in the blood), which can lead to long-term potentially serious complications. Conversely, excess phosphate intake can lead to hyperphosphatemia (high blood phosphorus levels), which occurs particularly in people with impaired kidney function and can lead to potentially serious electrolyte imbalances, adverse effects, or death.
In adults, phosphorus makes up approximately 1% of total body weight. It is present in every cell of the body, although 85% of the body's phosphorus is found in the bones and teeth.
Phosphates are used clinically to treat hypophosphatemia and hypercalcemia (high blood calcium levels), as saline laxatives, and in the management of calcium-based kidney stones. They may also be of some benefit to patients with vitamin D-resistant rickets, multiple sclerosis, and diabetic ketoacidosis (a very serious complication in which the body only uses fatty acids as fuel and produces acidic ketone bodies).
Based on the potential for side effects associated with high blood levels of phosphorus, phosphorus supplementation should be done only under medical supervision.

Evidence Table

These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. GRADE *
These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. GRADE *


Occasional constipation is a use of phosphates approved by the U.S. Food and Drug Administration (FDA) in adults and children, both in oral form and as an enema (for example, Fleet Enema). Phosphates are also used to restore bowel activity after surgery.

 A


Occasional constipation is a use of phosphates approved by the U.S. Food and Drug Administration (FDA) in adults and children, both in oral form and as an enema (for example, Fleet Enema). Phosphates are also used to restore bowel activity after surgery.

 A


Phosphate salts (except for calcium phosphate) are effective in the treatment of hypercalcemia. However, intravenous phosphate for treating hypercalcemia may not be recommended, due to concerns about lowering blood pressure, excessively lowering calcium levels, heart attack, tetany, or kidney failure. Sudden hypotension (low blood pressure), kidney failure, and death have been reported after phosphate infusion.

 A


Phosphate salts (except for calcium phosphate) are effective in the treatment of hypercalcemia. However, intravenous phosphate for treating hypercalcemia may not be recommended, due to concerns about lowering blood pressure, excessively lowering calcium levels, heart attack, tetany, or kidney failure. Sudden hypotension (low blood pressure), kidney failure, and death have been reported after phosphate infusion.

 A


Hypophosphatemia is an FDA-labeled use of phosphates in adults. Taking sodium phosphate or potassium phosphate is effective for preventing and treating most causes of hypophosphatemia and should be directed under medical supervision. The underlying cause of the hypophosphatemia should be identified and corrected whenever possible.

 A


Hypophosphatemia is an FDA-labeled use of phosphates in adults. Taking sodium phosphate or potassium phosphate is effective for preventing and treating most causes of hypophosphatemia and should be directed under medical supervision. The underlying cause of the hypophosphatemia should be identified and corrected whenever possible.

 A


Kidney stones (nephrolithiasis) are an FDA-labeled use of phosphates in adults. Taking potassium and sodium phosphate salts orally may help prevent kidney stones in patients with hypercalciuria (high urine calcium levels) and in patients with kidney stones made of calcium oxalate. However, phosphate administration when stones are composed of magnesium-ammonium-phosphate or calcium phosphate may increase the rate of stone formation.

 A


Kidney stones (nephrolithiasis) are an FDA-labeled use of phosphates in adults. Taking potassium and sodium phosphate salts orally may help prevent kidney stones in patients with hypercalciuria (high urine calcium levels) and in patients with kidney stones made of calcium oxalate. However, phosphate administration when stones are composed of magnesium-ammonium-phosphate or calcium phosphate may increase the rate of stone formation.

 A


This is an FDA-labeled use of phosphates in adults and children. Sodium phosphate taken orally or as an enema may be used for bowel cleansing in preparation for surgery, imaging studies, or endoscopy (for example, Fleet Phospho-soda?, Fleet Enema). Phosphates appear to increase peristalsis and cause an influx of fluids into the intestine via osmotic action. Aluminum phosphate is used orally to neutralize gastric acid.

 A


This is an FDA-labeled use of phosphates in adults and children. Sodium phosphate taken orally or as an enema may be used for bowel cleansing in preparation for surgery, imaging studies, or endoscopy (for example, Fleet Phospho-soda?, Fleet Enema). Phosphates appear to increase peristalsis and cause an influx of fluids into the intestine via osmotic action. Aluminum phosphate is used orally to neutralize gastric acid.

 A


After periods of severe malnutrition or starvation (for example, anorexia nervosa), intravenous phosphate may be necessary in order to prevent a refeeding syndrome. Phosphate levels should be closely monitored in such patients.

 B


After periods of severe malnutrition or starvation (for example, anorexia nervosa), intravenous phosphate may be necessary in order to prevent a refeeding syndrome. Phosphate levels should be closely monitored in such patients.

 B


Early research shows that high amounts of phosphorus may have negative effects on bone density. This is because phosphorus decreases bone formation and increases bone resorption. In clinical research, there was a lack of an association between milk intake and hip fracture in women. Milk is a source of phosphorus, as are calcium, protein, and supplementary vitamin D in certain countries, such as the United States. Well-designed studies are needed to confirm these findings.

 C


Early research shows that high amounts of phosphorus may have negative effects on bone density. This is because phosphorus decreases bone formation and increases bone resorption. In clinical research, there was a lack of an association between milk intake and hip fracture in women. Milk is a source of phosphorus, as are calcium, protein, and supplementary vitamin D in certain countries, such as the United States. Well-designed studies are needed to confirm these findings.

 C


Patients with serious burns may lose phosphate, and replacement may be necessary. Well-designed clinical trials are necessary before conclusions may be drawn.

 C


Patients with serious burns may lose phosphate, and replacement may be necessary. Well-designed clinical trials are necessary before conclusions may be drawn.

 C


The use of prophylactic phosphate therapy in diabetic ketoacidosis (a very serious complication in which the body only uses fatty acids as fuel and produces acidic ketone bodies) is controversial and may be considered, particularly in cases of low phosphate levels. In general, phosphate replacement is not routinely recommended, based on the lack of clinical benefit in some studies, as well as the potential for adverse effects, such as hypocalcemia and soft tissue calcification. In cases of low phosphate levels, some potassium replacement may be provided as potassium phosphate. Well-designed clinical trials are still necessary.

 C


The use of prophylactic phosphate therapy in diabetic ketoacidosis (a very serious complication in which the body only uses fatty acids as fuel and produces acidic ketone bodies) is controversial and may be considered, particularly in cases of low phosphate levels. In general, phosphate replacement is not routinely recommended, based on the lack of clinical benefit in some studies, as well as the potential for adverse effects, such as hypocalcemia and soft tissue calcification. In cases of low phosphate levels, some potassium replacement may be provided as potassium phosphate. Well-designed clinical trials are still necessary.

 C


Evidence is mixed with respect to the effect of oral phosphates on exercise performance. Further research is needed.

 C


Evidence is mixed with respect to the effect of oral phosphates on exercise performance. Further research is needed.

 C


Long-term, slow-release neutral potassium phosphate has been shown to reduce calcium excretion in subjects with absorptive hypercalciuria, and it appears to be well tolerated. This use of phosphates may be considered to prevent kidney stone formation. Further research is required.

 C


Long-term, slow-release neutral potassium phosphate has been shown to reduce calcium excretion in subjects with absorptive hypercalciuria, and it appears to be well tolerated. This use of phosphates may be considered to prevent kidney stone formation. Further research is required.

 C


Hyperparathyroidism is the overactivity of the parathyroid glands. This results in excess production of parathyroid hormone (PTH), involved in the regulation of calcium and phosphate levels. At least in some patients with hyperparathyroidism, serum phosphate levels are low. However, well-designed clinical trials investigating the use of phosphates for this purpose are lacking, and further research is required.

 C


Hyperparathyroidism is the overactivity of the parathyroid glands. This results in excess production of parathyroid hormone (PTH), involved in the regulation of calcium and phosphate levels. At least in some patients with hyperparathyroidism, serum phosphate levels are low. However, well-designed clinical trials investigating the use of phosphates for this purpose are lacking, and further research is required.

 C


The effect of the addition of calcium and phosphorus to human milk on growth and bone metabolism in preterm infants is unclear. Further research is needed.

 C


The effect of the addition of calcium and phosphorus to human milk on growth and bone metabolism in preterm infants is unclear. Further research is needed.

 C


Critically ill patients receiving intravenous feedings often have low phosphate levels. Phosphate levels should be closely monitored in such patients, particularly if kidney function is impaired. Inorganic phosphates avoid incompatibility with calcium in TPN solutions. The addition of phosphate to TPN solutions should be under the supervision of a licensed nutritionist.

 C


Critically ill patients receiving intravenous feedings often have low phosphate levels. Phosphate levels should be closely monitored in such patients, particularly if kidney function is impaired. Inorganic phosphates avoid incompatibility with calcium in TPN solutions. The addition of phosphate to TPN solutions should be under the supervision of a licensed nutritionist.

 C


Vitamin D-resistant rickets is a fairly common type of rickets and is defined by its resistance to treatment with vitamin D. Low levels of phosphates are common in many of these patients. However, well-designed clinical trials investigating the use of phosphates for this purpose are lacking, and further research is required.

 C


Vitamin D-resistant rickets is a fairly common type of rickets and is defined by its resistance to treatment with vitamin D. Low levels of phosphates are common in many of these patients. However, well-designed clinical trials investigating the use of phosphates for this purpose are lacking, and further research is required.

 C
* Key to grades

A: Strong scientific evidence for this use
B: Good scientific evidence for this use
C: Unclear scientific evidence for this use
D: Fair scientific evidence for this use (it may not work)
F: Strong scientific evidence against this use (it likley does not work)
* Key to grades

A: Strong scientific evidence for this use
B: Good scientific evidence for this use
C: Unclear scientific evidence for this use
D: Fair scientific evidence for this use (it may not work)
F: Strong scientific evidence against this use (it likley does not work)

Tradition / Theory

The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.

Dosing

Adults (18 years and older)
The recommended daily intake has been suggested to be 700 milligrams of phosphorus daily for adults aged 18 years and older, including pregnant or breastfeeding women.
The tolerable upper intake level (UL) for adults 19-70 years old is four grams daily; for adults more than 70 years old, the UL is three grams daily. The recommended UL in pregnant women is 3.5 grams daily, and in breastfeeding women, it is four grams daily.
Phosphate salts should not be given to patients with hyperphosphatemia (high blood phosphorus levels) and should be used cautiously in those with impaired kidney function.
Doses typically range from one to three grams of phosphorus (as a phosphate salt (sodium phosphate or potassium phosphate) or elemental phosphate) daily by mouth for the treatment of calcium oxalate kidney stones, hypercalcemia, or hypophosphatemia. Doses are usually divided and taken throughout the day.
Fleet Enema (118 milliliters) can be used as a laxative when administered rectally. It should be administered as a single daily dose. Laxatives should not generally be used for more than one week. 4-8 grams of sodium phosphate dissolved in water has also been used as a saline laxative (it should be taken with plenty of water).
Intravenous phosphate 50 millimoles (sodium: 81 millimoles, potassium: 9.5 millimoles) over 24 hours has been used during refeeding syndrome when serum phosphate falls below 0.5 millimoles per liter. Phosphate blood levels should be closely followed.

Safety

The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.

Interactions

Interactions with Drugs
Antacids containing aluminum, calcium, or magnesium can bind phosphate in the gut and prevent its absorption, potentially leading to hypophosphatemia (low phosphate levels) when used chronically.
Some anticonvulsants (including phenobarbital and carbamazepine) may lower phosphorus levels and increase levels of alkaline phosphatase.
Bile acid sequestrants such as cholestyramine (Questran?) and colestipol (Colestid?) can decrease oral absorption of phosphate. Therefore, oral phosphate supplements should be administered at least one hour before or four hours after these agents.
Corticosteroids may increase urinary phosphorus levels.
Potassium supplements or potassium-sparing diuretics taken together with a phosphate may result in high blood levels of potassium (hyperkalemia).
Alcohol (ethanol) may increase urinary phosphorus. Wine may enhance absorption of phosphorus (as well as calcium and magnesium).
Calcimimetics and insulin may decrease blood levels of phosphorus.
Estrogen may increase urinary phosphorus.
Phosphate binders decrease blood levels of phosphorus.
Medications that may affect electrolyte levels should be used cautiously with phosphates. Examples include amiloride (Midamor?); angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin?), captopril (Capoten?), enalapril (Vasotec?), fosinopril (Monopril?), lisinopril (Zestril?, Prinivil?), quinapril (Accupril?), or ramipril (Altace?); cyclosporine; cardiac glycosides (Digoxin?); heparins; anti-inflammatory drugs; potassium-containing agents; salt substitutes; spironolactone (Aldactone?); and triamterene (Dyrenium?).
Phosphates may cause low blood pressure. Caution is advised in patients taking agents that lower blood pressure.
Phosphates may also interact with ACE inhibitors, cardiovascular agents, gastrointestinal agents, hepatotoxic agents, osteoporosis drugs, and renal agents.

Attribution

This information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com).

Bibliography

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Ehrenpreis ED, Nogueras JJ, Botoman VA, et al. Serum electrolyte abnormalities secondary to Fleet's Phospho-Soda colonoscopy prep. A review of three cases. Surg Endosc 1996;10(10):1022-1024.
Fakiris AJ, Moore DH, Reddy SR, et al. Intraperitoneal radioactive phosphorus (32P) and vaginal brachytherapy as adjuvant treatment for uterine papillary serous carcinoma and clear cell carcinoma: a phase II Hoosier Oncology Group (HOG 97-01) study. Gynecol Oncol 2005;96(3):818-823.
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Kastenberg D, Chasen R, Choudhary C, et al. Efficacy and safety of sodium phosphate tablets compared with PEG solution in colon cleansing: two identically designed, randomized, controlled, parallel group, multicenter phase III trials. Gastrointest Endosc 2001;54(6):705-713.
Kemi VE, K?rkk?inen MU, Lamberg-Allardt CJ. High phosphorus intakes acutely and negatively affect Ca and bone metabolism in a dose-dependent manner in healthy young females. Br J Nutr. 2006 Sep;96(3):545-52.
Kuschel CA, Harding JE. Calcium and phosphorus supplementation of human milk for preterm infants. Cochrane Database Syst Rev. 2001;(4):CD003310.
Kurihara S, Tsuruta Y, Akizawa T. Effect of MCI-196 (colestilan) as a phosphate binder on hyperphosphataemia in aemodialysis patients: a double-blind, placebo-controlled, short-term trial. Nephrol Dial Transplant 2005;20(2):424-430.
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