Cusparia febrifuga

Related Terms

Allocspariene, Angostura trifoliata, Angostura trifoliate, Bonplandia trifoliata Willd., candicine, Cusparia febrifuga Humb. ex DC., Cusparia felorifuga, Cusparia trifoliata (Willd.) Engl., Galipea, Galipea officinalis, galipinine, quinolones, Rutaceae (family), tetrahydroquinolines.

Background

Angostura (Galipea officinalis, Angostura trifoliata) is a shrub-like tree that has been studied for its potential antibiotic and cytotoxic (cell killing) activity. The bark is thought to be the main source of its medicinal properties.
Although the angostura tree and Angostura? aromatic bitters bear the same name, the bitters were named after the city, Angostura, Venezuela, and the proprietary formula is not said to contain angostura.
There is not enough human data available to support the use of angostura for any indication.

Evidence Table

These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. GRADE *
These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. GRADE *
* Key to grades

A: Strong scientific evidence for this use
B: Good scientific evidence for this use
C: Unclear scientific evidence for this use
D: Fair scientific evidence for this use (it may not work)
F: Strong scientific evidence against this use (it likley does not work)
* Key to grades

A: Strong scientific evidence for this use
B: Good scientific evidence for this use
C: Unclear scientific evidence for this use
D: Fair scientific evidence for this use (it may not work)
F: Strong scientific evidence against this use (it likley does not work)

Tradition / Theory

The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.

Dosing

Adults (18 years and older)
There is no proven safe or effective dose for angostura.

Safety

The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.

Interactions

Interactions with Drugs
Angostura may interact with anti-malaria or anti-cancer drugs.
Angostura may interact with antibiotics that fight tuberculosis-causing bacteria.

Attribution

This information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com).

Bibliography

Houghton PJ, Woldemariam TZ, Watanabe Y, et al. Activity against Mycobacterium tuberculosis of alkaloid constituents of Angostura bark, Galipea officinalis. Planta Med 1999;65(3):250-254.
Jacquemond-Collet I, Benoit-Vical F, Valentin A, et al. Antiplasmodial and cytotoxic activity of galipinine and other tetrahydroquinolines from Galipea officinalis. Planta Med 2002;68(1):68-69.
Jacquemond-Collet I, Bessiere JM, Hannedouche S, et al. Identification of the alkaloids of Galipea officinalis by gas chromatography-mass spectrometry. Phytochem Anal 2001;12(5):312-319.
Jacquemond-Collet I, Hannedouche S, Fouraste I, et al. Novel quinoline alkaloid from trunk bark of Galipea officinalis. Fitoterapia 2000;71(5):605-606.
Rakotoson JH, Fabre N, Jacquemond-Collet I, et al. Alkaloids from Galipea officinalis. Planta Med 1998;64(8):762-763.