Extrait de pousses de brocoli

Related Terms

4-Methylsulfinylbutylnitrile, 5-methylsulfinylpentylnitrile, Brassicaceae (family), Broccoli Super Sprout, BroccoSprouts?, Cruciferae (family), glucoiberin, glucoraphanin, glucosinolates, isothiocyanates, sulforaphane, sulforaphane [(-)-1-isothiocyanato-(4R)-(methylsulfinyl)butane], sulforaphane-cysteine, sulforaphane-cysteine-glycine, sulforaphane-glutathione, sulforaphane-N-acetylcysteine.
Note: This monograph includes information about the effects of broccoli, broccoli sprouts, and broccoli sprout extract.

Background

Broccoli sprouts are broccoli plants that are 3-4 days old. They look like alfalfa sprouts but taste like radish.
Sulforaphane is a chemical that is found in high amounts in broccoli and broccoli sprouts. Some brands, such as Brassica's BroccoSprouts?, may contain more than 20 times more sulforaphane than mature broccoli. Sulforaphane has been shown to have anticancer and antioxidant effects.
According to a review, sulforaphane and other similar chemicals have been studied in for cancer prevention.
Daily intake of broccoli sprouts may also be an effective treatment for Helicobacter pylori infection, which may cause stomach ulcers. Higher-quality human studies are needed before further conclusions may be drawn.

Evidence Table

These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. GRADE *
These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. GRADE *


Laboratory and animal studies have shown that fresh broccoli sprout extracts, as well as sulforaphane alone, may have anti-Helicobacter activity. More human studies in this area are needed.

 C


Laboratory and animal studies have shown that fresh broccoli sprout extracts, as well as sulforaphane alone, may have anti-Helicobacter activity. More human studies in this area are needed.

 C


Early research suggests that broccoli sprout extract applied to the skin may protect against erythema (abnormal redness of the skin) caused by exposure to ultraviolet (UV) radiation. Additional studies of higher quality are needed to confirm these results.

 C


Early research suggests that broccoli sprout extract applied to the skin may protect against erythema (abnormal redness of the skin) caused by exposure to ultraviolet (UV) radiation. Additional studies of higher quality are needed to confirm these results.

 C
* Key to grades

A: Strong scientific evidence for this use
B: Good scientific evidence for this use
C: Unclear scientific evidence for this use
D: Fair scientific evidence for this use (it may not work)
F: Strong scientific evidence against this use (it likley does not work)
* Key to grades

A: Strong scientific evidence for this use
B: Good scientific evidence for this use
C: Unclear scientific evidence for this use
D: Fair scientific evidence for this use (it may not work)
F: Strong scientific evidence against this use (it likley does not work)

Tradition / Theory

The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.

Dosing

Adults (18 years and older)
For preventing cancer, eating 1/2 cup of broccoli sprouts two or three times weekly has been suggested.
For treating Helicobacter pylori infections, 70 grams of Broccoli Super Sprout, which contains 420 micromoles of glucoraphanin per liter, has been given by mouth daily for eight weeks.
For protecting against erythema (abnormal redness of the skin) caused by radiation damage, broccoli sprout extract (containing 100, 200, 400, or 600 nanomoles of sulforaphane (SF) per liter) has been applied to the skin.

Safety

The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.

Interactions

Interactions with Drugs
Broccoli sprouts containing glucoraphanin may cause low blood pressure. Caution is advised in people taking agents that lower blood pressure.
Sulforaphane, a chemical found in broccoli sprouts, may interfere with the way the body processes certain drugs using the liver's cytochrome P450 enzyme system. As a result, the levels of these drugs may be increased in the blood and may cause increased effects or potentially serious adverse reactions. People using any medications should check the package insert and speak with a qualified healthcare professional, including a pharmacist, about possible interactions.
Broccoli sprouts may interact with cholesterol-lowering agents and ultraviolet protective agents.

Attribution

This information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com).

Bibliography

Berg M, Brierly D, Carlson M, et al. Vegetable Medication. Men's Fitness 2003;19(7):42.
Dinkova-Kostova AT, Fahey JW, Benedict AL, et al. Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice. Photochem.Photobiol.Sci 2010;9(4):597-600.
Dinkova-Kostova AT, Jenkins SN, Fahey JW, et al. Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts. Cancer Lett. 8-28-2006;240(2):243-252.
Donaldson MS. Nutrition and cancer: a review of the evidence for an anti-cancer diet. Nutr J 10-20-2004;3:19.
Fahey JW, Haristoy X, Dolan PM, et al. Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. Proc Natl Acad Sci U.S.A. 5-28-2002;99(11):7610-7615.
Fighting cancer at the grocery store. Research shows broccoli sprouts, cabbage, garlic, among other vegetables, contain anti-cancer properties. Health News 2006;12(1):10-11.
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Johnston N. Sulforaphane halts breast cancer cell growth. Drug Discov.Today 11-1-2004;9(21):908.
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Murashima M, Watanabe S, Zhuo XG, Uehara M, Kurashige A. Phase 1 study of multiple biomarkers for metabolism and oxidative stress after one-week intake of broccoli sprouts. Biofactors 2004;22(1-4):271-275.
Park EJ, Pezzuto JM. Botanicals in cancer chemoprevention. Cancer Metastasis Rev 2002;21(3-4):231-255.
Talalay P, Fahey JW, Healy ZR, et al. Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation. Proc Natl Acad Sci U S A 10-30-2007;104(44):17500-17505.
Wu L, Noyan Ashraf MH, Facci M, et al. Dietary approach to attenuate oxidative stress, hypertension, and inflammation in the cardiovascular system. Proc Natl Acad Sci U S A 5-4-2004;101(18):7094-7099.
Yanaka A, Fahey JW, Fukumoto A, et al. Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans. Cancer Prev Res (Phila) 2009;2(4):353-360.