Flavonoid

Related Terms

2'-Chlorochrysin, 5,7-dihydroxyflavone, 5,7-dimethoxy-8-iodochrysin, 5,7-dimethoxyflavone, 6-deoxy-6-desmethyl-4-desdimethylamino-tetracycline, 7-(4"-O-acetyl)-O-beta-D-glucopyranoside, 7-(6"-O-acetyl)-O-beta-D-glucopyranoside, 8-bromo-5-hydroxy-7-methoxychrysin, acacetin-7-O-beta-D-galactopyranoside, alcohols, alkaloids, almindelig passionsblomst (Danish), amino acids, apricot vine, Australian fever-tree, baical skullcap, Baikal skullcap, balm of Gilead, bl? passionsblomma (Swedish), black poplar, blaue Passionsblume (German), blauwe passiebloem (Dutch), blue crown passionflower, blue passionflower, blue-crown passionflower, Calicotome villosa, carrot, Cerasus vulgaris Miller, cherry, chrisina (Portuguese - Brazil), Christ's thorn, Chrysanthemum morifolium, clock flower, clock plant, common skullcap, coumarins, crisina (Portuguese - Brazil), Daucus carota Linn., Daucus carota ssp. carota, dietary flavonoids, diethyl chrysin-7-yl phosphate, eastern white pine, Eriodictyon californicum (Hook. et Arn.) Torr., espina de Cristo (Spanish), ?szak-amerikai golgotavir?g (Hunagarian), Eucalyptus globulus Labill., flavone X, flavonoid, fleischfarbene Passionsblume (German), fleur de la passion (French), flor de pasi?n (Spanish), flower of the five wounds, galangin flavanone, genet, hardy garden mum, honey, k?rsimyskukka (Finnish), l?kepassionsblomma (Swedish), Leiden Christi (German), lillikoi, Manzana de Mayo, maracuja (Spanish), maracuj? (Portuguese - Brazil), maracuj?-azul (Portuguese - Brazil), mayapple, maypop, maypop herb, maypop passionflower, meczennica krwista (Polish), Mother-of-God's Star, mucenka jedl? (Czech), mucenka modr? (Czech), Muttergottes-Schuzchen (German), oak-leaved geranium, pasiflora (Spanish), pasionaria (Spanish), pasjonsblomst (Norwegian), Passiflora caerulea, Passiflora coerulea L., Passiflora edulis, Passifloraincarnata, Passifloraincarnate, Passifloraceae (family), passiflore (French), passiflore sauvage (French), passion flower, passion vine, passionblomma (Swedish), passionflower, Passionsblume (German), passionsblomst (Danish), Passionskraut (German), Pelargonium quercifoleum, phenylbenzopyrones, phytoestrogens, Pinus strobus L., Populus balsamifera L., Populus balsamifera var. hortensis, Populus nigra L., Populus tacamahaca Mill., Populus tacamahacca Mill., propolis, Prunus cerasus L., punakas kannatuslill (Estonian), purple passionflower, Scutellaria baicalensis, Scutellaria baicalensis Georgi, Scutellaria galericulata L., Scutellaria macrantha Fisch., sinine kannatuslill (Estonian), Spartium junceum L., sugars, tetraethyl bis-phosphoric ester of chrysin, vill pasjonsblomst (Norwegian), wild passionflower, winterharte Passionsblume (German), yerba santa.
Combination products: ANDRO-6 (containing 625 milligrams of chrysin, 300 milligrams of androstenedione, 150 milligrams of DHEA, 750 milligrams of Tribulus terrestris, 300 milligrams of indole-3-carbinol, and 540 milligrams of saw palmetto).

Background

Chrysin is a flavonoid, a compound found in fruits and vegetables. Flavonoids give plants their color and may have antibacterial effects.
Chrysin generally comes from passionflower (Passiflora incarnata and other Passiflora species) and is found in other plants, like yerba santa, Australian fever tree, eastern white pine, balm of Gilead, black poplar, Baikal skullcap, common skullcap, and genet (Spartium junceum L.), as well as in small amounts in honey and other bee products.
Research has found that chrysin may block aromatase, a compound that turns testosterone into estrogen. Because of this, it is believed that chrysin may help bodybuilders. Chrysin has also been studied for use in heart disease and cancer prevention and treatment. However, evidence is lacking, and more research is needed.

Evidence Table

These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. GRADE *
These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. GRADE *
* Key to grades

A: Strong scientific evidence for this use
B: Good scientific evidence for this use
C: Unclear scientific evidence for this use
D: Fair scientific evidence for this use (it may not work)
F: Strong scientific evidence against this use (it likley does not work)
* Key to grades

A: Strong scientific evidence for this use
B: Good scientific evidence for this use
C: Unclear scientific evidence for this use
D: Fair scientific evidence for this use (it may not work)
F: Strong scientific evidence against this use (it likley does not work)

Tradition / Theory

The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.

Dosing

Adults (18 years and older)
To improve exercise performance, a combination product (ANDRO-6; containing 625 milligrams of chrysin, 300 milligrams of androstenedione, 150 milligrams of DHEA, 750 milligrams of Tribulus terrestris, 300 milligrams of indole-3-carbinol, and 540 milligrams of saw palmetto) has been taken by mouth daily for eight weeks.

Safety

The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.

Interactions

Interactions with Drugs
Chrysin may increase the risk of bleeding when taken with drugs that increase the risk of bleeding. Some examples include aspirin, anticoagulants (blood thinners) such as warfarin (Coumadin?) or heparin, antiplatelet drugs such as clopidogrel (Plavix?), and nonsteroidal anti-inflammatory drugs such as ibuprofen (Motrin?, Advil?) or naproxen (Naprosyn?, Aleve?).
Chrysin may cause low blood pressure. Caution is advised in people taking drugs that lower blood pressure.
Chrysin may interfere with the way the body processes certain drugs using the liver's cytochrome P450 enzyme system. As a result, the levels of these drugs may be increased in the blood and may cause increased effects or potentially serious adverse reactions. People using any medications should check the package insert and speak with a qualified healthcare professional, including a pharmacist, about possible interactions.
Chrysin may also react with agents that may increase sensitivity to light, agents that may lower seizure threshold, agents that may treat cancer, antibiotics, and hormonal agents.

Attribution

This information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com).

Bibliography

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