Kan Jang?

Related Terms

14-deoxy-11,12-didehydroandrographolide, Andrographis paniculata Nees, andrographolide, Chuan Xin Lin, Green chiretta, KalmColdT, Kalmegh leaf extract, Kan Jang?, King of Bitters, Kold Kare?, neoandrographolide, Nain-e Havandi, Remdex?.
Combination product examples: Ayurvedic Blood Sugar Formula (Andrographis paniculata herb, sylvestre leaf, Momordicacharantia fruit bark, Pterocarpus marsupium gum, Aegle marmelos leaf, Enicostemma littorale herb, curcuma), Chuan Xin Lian (Healing Herbs of China), Immunoguard? (Eleutherococcus senticosus, Schizandra chinensis, Glycyrrhiza glabra), Immuno Shield100? Bioflavonoid complex (Andrographis paniculata, garlic clove powder, astragalus root extract), Jarrow Tribulus complex? (100mg Andrographis paniculata extract, Withania somnifera root), Kan Jang? (Swedish Herbal Institute, SHA-10 standardized extract), Kold-Kare?, Nature's Sunshine Products (proprietary blend 470mg Andrographis paniculata herb extract, thyme herb), Nature's Way Andrographis, Solaray Andrographis 300mg, Planetary Formulas Andrographis, Plum Flower Brand Andrographis, SHA-10 (Swedish Herbal Institute).

Background

The leaves of Andrographis paniculata have been a part of Indian folk medicine and Ayurveda for centuries. The Chinese and Thai herbal medicine systems have also used this herb, mostly for its "bitter" properties, as a treatment for digestive problems and for a variety of fever-causing illnesses. More recently, this herb has become popular in Scandinavia as a remedy for upper lung infections and the flu.
The most widely tested product is called Kan Jang? (Swedish Herbal Institute). This product is available with andrographis alone and in combination with Eleutherococcus senticosus.
There is strong evidence from clinical trials to suggest that andrographis effectively reduces the severity and the duration of upper lung infections. According to early studies, andrographis may have a number of other potential therapeutic uses, including as an anti-inflammatory agent and as a treatment for chemically-induced liver damage. It has also been studied in human clinical trials for the flu and familial Mediterranean fever.
Serious side effects have not been seen; however, at higher doses toxicities may occur.

Evidence Table

These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. GRADE *
These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. GRADE *


Research suggests that andrographis may reduce symptom severity and duration in active infections if started within 36-48 hours after symptoms develop. Additional studies are needed, especially those that test the effects of andrographis alone.

 A


Research suggests that andrographis may reduce symptom severity and duration in active infections if started within 36-48 hours after symptoms develop. Additional studies are needed, especially those that test the effects of andrographis alone.

 A


Early research has shown that andrographis has anti-inflammatory effects. This may play a role in the therapy of stomach and intestinal disorders that have inflammatory associations, such as ulcerative colitis. Clinical research has shown andrographis to have a positive clinical response that was significantly different than placebo; however, differences in clinical remission rates were lacking between groups. When compared to standard therapy, there was a lack of significant difference for symptom score reduction and for remission based on colonoscopy results. Further research is needed to determine if andrographis has a role in ulcerative colitis therapy.

 B


Early research has shown that andrographis has anti-inflammatory effects. This may play a role in the therapy of stomach and intestinal disorders that have inflammatory associations, such as ulcerative colitis. Clinical research has shown andrographis to have a positive clinical response that was significantly different than placebo; however, differences in clinical remission rates were lacking between groups. When compared to standard therapy, there was a lack of significant difference for symptom score reduction and for remission based on colonoscopy results. Further research is needed to determine if andrographis has a role in ulcerative colitis therapy.

 B


Familial Mediterranean fever is a genetic disorder that mainly affects ethnic groups around the Mediterranean causing recurrent episodes of fever and swelling of serous membranes. While early studies suggest that a combination product containing andrographis may reduce the duration, frequency, and severity of attacks among children, more studies using andrographis alone are needed.

C


Familial Mediterranean fever is a genetic disorder that mainly affects ethnic groups around the Mediterranean causing recurrent episodes of fever and swelling of serous membranes. While early studies suggest that a combination product containing andrographis may reduce the duration, frequency, and severity of attacks among children, more studies using andrographis alone are needed.

C


Early studies suggest that andrographis may reduce the duration and severity of flu symptoms, as well as the amount of sick time taken off from work by patients with the flu. More research is needed to confirm these results.

 C


Early studies suggest that andrographis may reduce the duration and severity of flu symptoms, as well as the amount of sick time taken off from work by patients with the flu. More research is needed to confirm these results.

 C


Early studies suggest that andrographis extract may help prevent URIs during the winter months if taken daily. Larger studies are required to confirm these results.

 C


Early studies suggest that andrographis extract may help prevent URIs during the winter months if taken daily. Larger studies are required to confirm these results.

 C


Early research has shown that andrographis has anti-inflammatory effects. This may offer a role in conditions that have inflammatory associations, such as rheumatoid arthritis (RA). The effects of an andrographis extract were evaluated in people with RA. Evidence of benefit was seen compared to baseline, however, there was a lack of significance when compared to placebo. Further research is therefore needed in order to establish a firm conclusion.

 D


Early research has shown that andrographis has anti-inflammatory effects. This may offer a role in conditions that have inflammatory associations, such as rheumatoid arthritis (RA). The effects of an andrographis extract were evaluated in people with RA. Evidence of benefit was seen compared to baseline, however, there was a lack of significance when compared to placebo. Further research is therefore needed in order to establish a firm conclusion.

 D
* Key to grades

A: Strong scientific evidence for this use
B: Good scientific evidence for this use
C: Unclear scientific evidence for this use
D: Fair scientific evidence for this use (it may not work)
F: Strong scientific evidence against this use (it likley does not work)
* Key to grades

A: Strong scientific evidence for this use
B: Good scientific evidence for this use
C: Unclear scientific evidence for this use
D: Fair scientific evidence for this use (it may not work)
F: Strong scientific evidence against this use (it likley does not work)

Tradition / Theory

The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.

Dosing

Adults (over 18 years old)
Even though not well studied in clinical trials, typical amounts of leaf preparation are doses of 500-3,000 milligrams of andrographis leaf taken by mouth three times daily.
For rheumatoid arthritis, an extract containing 30 milligrams of andrographolides was given by mouth three times daily for 14 weeks with a lack of benefit compared to placebo.
For ulcerative colitis, 400 milligrams of an extract containing 8-10% andrographis by weight has been used three times daily for eight weeks. In addition, 1,200 or 1,800 milligrams of an andrographis extract has been taken by mouth daily in three divided doses for eight weeks.
For upper lung infection treatment, 3-6 grams (containing 48-500 milligrams of the andrographolides) divided into 3-4 daily doses, has been taken by mouth for 4-10 days. In addition, 100 milligrams KalmColdT (an extract) has been taken by mouth twice daily after dinner and breakfast for five days. A 1,200 milligrams Kan Jang? tablet has also been taken by mouth daily (duration unclear).
For upper lung infection prevention, 200 milligrams of andrographis has been taken by mouth daily as two Kan Jang? tablets for three months. Use appears to be safe for up to two weeks. Higher doses may be unsafe, leading to side effects.

Safety

The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.

Interactions

Interactions with Drugs
Andrographis may increase the risk of bleeding. Use cautiously in patients taking anticoagulant agents, such as warfarin (Coumadin?) or heparin or with anti-platelet agents such as ibuprofen (Motrin?, Advil?) or clopidogrel (Plavix?). Andrographis use should be stopped before some surgeries; discuss this with a healthcare professional.
Andrographis may lower blood pressure and may therefore, add to the effects of drugs taken to lower blood pressure. Patients with high or low blood pressure who are considering taking any of these agents should discuss options with their healthcare professionals. Dosing adjustments may be necessary.
Andrographis may decrease blood sugar and may add to the effects of drugs taken to lower blood sugar, including insulin. Patients should be closely monitored by their healthcare professionals because dosing adjustments may be necessary.
Andrographis may also interact with agents for fever, agents for pain, agents for stomach acid, stomach and intestine disorders, and ulcers, agents for the skin, agents that affect nerves, allergy, anti-cancer, anti-inflammatory, antiviral, birth control, fertility, and immunomodulatory agents.

Attribution

This information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com).

Bibliography

Akbar S. Andrographis paniculata: a review of pharmacological activities and clinical effects. Altern.Med Rev. 2011;16(1):66-77.
Aromdee C. Modifications of andrographolide to increase some biological activities: a patent review (2. Expert.Opin.Ther Pat 2012;22(2):169-180.
Burgos RA, Hancke JL, Bertoglio JC, et al. Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled trial. Clin Rheumatol. 2009;28(8):931-946.
Burns JJ, Zhao L, Taylor EW, et al. The influence of traditional herbal formulas on cytokine activity. Toxicology 11-28-2010;278(1):140-159.
Chandrasekaran CV, Murali B, Deepak M, et al. In vitro comparative evaluation of non-leaves and leaves extracts of Andrographis paniculata on modulation of inflammatory mediators. Antiinflamm.Antiallergy.Agents Med Chem 2012;11(2):191-197.
Chen Q, Liu Y, Liu YM, et al. Pharmacokinetics and tolerance of dehydroandrographolide succinate injection after intravenous administration in healthy Chinese volunteers. Acta Pharmacol Sin. 2012;33(10):1332-1336.
Ghosh N, Ghosh R, Mandal V, et al. Recent advances in herbal medicine for treatment of liver diseases. Pharm Biol 2011;49(9):970-988.
Kibirev VK and Osadchuk TV. [Structure and properties of proprotein convertase inhibitors]. Ukr.Biokhim.Zh. 2012;84(2):5-29.
Kuttan G, Pratheeshkumar P, Manu KA, et al. Inhibition of tumor progression by naturally occurring terpenoids. Pharm Biol 2011;49(10):995-1007.
Lim JC, Chan TK, Ng DS, et al. Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer. Clin Exp.Pharmacol Physiol 2012;39(3):300-310.
Sandborn WJ, Targan SR, Byers VS, et al. Andrographis paniculata extract (HMPL-004) for active ulcerative colitis. Am J Gastroenterol. 2013;108(1):90-98.
Saxena RC, Singh R, Kumar P, et al. A randomized double blind placebo controlled clinical evaluation of extract of Andrographis paniculata (KalmCold) in patients with uncomplicated upper respiratory tract infection. Phytomedicine. 2010;17(3-4):178-185.
Singh P, Singh IN, Mondal SC, et al. Platelet-activating factor (PAF)-antagonists of natural origin. Fitoterapia 2013;84:180-201.
Tang T, Targan SR, Li ZS, et al. Randomised clinical trial: herbal extract HMPL-004 in active ulcerative colitis - a double-blind comparison with sustained release mesalazine. Aliment.Pharmacol Ther 2011;33(2):194-202.
Valdiani A, Kadir MA, Tan SG, et al. Andrographis paniculata present yesterday, absent today: a plenary review on underutilized herb of Iran's pharmaceutical plants. Mol.Biol Rep. 2012;39(5):5409-5424.