Phellinus linteus

Related Terms

Aoshima medicinal mushroom, bai hua rong, hispidin, hispolon, Hymenochaetaceae (family), interfungins A, lintenole, keumsa sangwhang mushroom, meshimakobu (Japanese), mud mushroom, mulberry yellow, ohnovec hartiguv (Czech), polypore, song gen (Chinese), phellinone, Phellinus linteus, sang-hwang (Korean), suanghuang (Chinese), teng.

Background

Sanghuang (Phellinus linteus) is a medicinal mushroom that has reportedly been used in Asian countries for centuries for a variety of ailments, including inflammation, gastrointestinal problems, and cancer.
Although human clinical trials are lacking, sanghuang has been used to treat cancer in a few cases. In preliminary research, sanghuang has been shown to reduce tumor size, prevent metastasis in a variety of cancers, and enhance the beneficial effects of several anticancer drugs when used in combination therapy.

Evidence Table

These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. GRADE *
These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. GRADE *


Although human evidence is lacking, sanghuang has been shown to have anticancer properties. Further research is required before a conclusion can be made.

 C


Although human evidence is lacking, sanghuang has been shown to have anticancer properties. Further research is required before a conclusion can be made.

 C
* Key to grades

A: Strong scientific evidence for this use
B: Good scientific evidence for this use
C: Unclear scientific evidence for this use
D: Fair scientific evidence for this use (it may not work)
F: Strong scientific evidence against this use (it likley does not work)
* Key to grades

A: Strong scientific evidence for this use
B: Good scientific evidence for this use
C: Unclear scientific evidence for this use
D: Fair scientific evidence for this use (it may not work)
F: Strong scientific evidence against this use (it likley does not work)

Tradition / Theory

The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.

Dosing

Adults (18 years and older)
There is no proven safe or effective dose for sanghuang in adults.

Safety

The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.

Interactions

Interactions with Drugs
Sanghuang may interfere with the way the body processes certain drugs using the liver's cytochrome P450 enzyme system. As a result, the levels of these drugs may be increased or decreased in the blood and may cause increased effects or potentially serious adverse reactions. People using any medications should check the package insert and speak with a qualified healthcare professional, including a pharmacist, about possible interactions.
Sanghuang may also interact with Alzheimer's agents, antibiotics, anticancer agents, antihistamines, anti-inflammatory agents, antiulcer agents, agents that inhibit growth of blood vessels, agents that affect the immune system, and cholesterol-lowering agents.

Attribution

This information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com).

Bibliography

Chen, W., He, F. Y., and Li, Y. Q. The apoptosis effect of hispolon from Phellinus linteus (Berkeley & Curtis) Teng on human epidermoid KB cells. J Ethnopharmacol. 4-21-2006;105(1-2):280-285.
Choi, Y. H., Yan, G. H., Chai, O. H., et al. Inhibition of anaphylaxis-like reaction and mast cell activation by water extract from the fruiting body of Phellinus linteus. Biol Pharm.Bull. 2006;29(7):1360-1365.
Choi, S. B., Park, C. H., Choi, M. K., et al. Improvement of insulin resistance and insulin secretion by water extracts of Cordyceps militaris, Phellinus linteus, and Paecilomyces tenuipes in 90% pancreatectomized rats. Biosci.Biotechnol.Biochem. 2004;68(11):2257-2264.
Hur, J. M., Yang, C. H., Han, S. H., et al. Antibacterial effect of Phellinus linteus against methicillin-resistant Staphylococcus aureus. Fitoterapia 2004;75(6):603-605.
Kim, G. Y., Lee, J. Y., Lee, J. O., et al. Partial characterization and immunostimulatory effect of a novel polysaccharide-protein complex extracted from Phellinus linteus. Biosci.Biotechnol.Biochem. 2006;70(5):1218-1226.
Kim, G. Y., Choi, G. S., Lee, S. H., et al. Acidic polysaccharide isolated from Phellinus linteus enhances through the up-regulation of nitric oxide and tumor necrosis factor-alpha from peritoneal macrophages. J Ethnopharmacol. 2004;95(1):69-76.
Lee, H. J., Lee, H. J., Lim, E. S., et al. Cambodian Phellinus linteus inhibits experimental metastasis of melanoma cells in mice via regulation of urokinase type plasminogen activator. Biol Pharm.Bull. 2005;28(1):27-31.
Lee, Y. S., Kang, Y. H., Jung, J. Y., et al. Inhibitory constituents of aldose reductase in the fruiting body of Phellinus linteus. Biol Pharm.Bull. 2008;31(4):765-768.
Lim, B. O., Jeon, T. I., Hwang, S. G., et al. Phellinus linteus grown on germinated brown rice suppresses IgE production by the modulation of Th1/Th2 balance in murine mesenteric lymph node lymphocytes. Biotechnol.Lett. 2005;27(9):613-617.
Matsuba, S., Matsuno, H., Sakuma, M., et al. Phellinus linteus Extract Augments the Immune Response in Mitomycin C-Induced Immunodeficient Mice. Evid.Based.Complement Alternat.Med 2008;5(1):85-90.
Nam, S. W., Han, J. Y., Kim, J. I., et al. Spontaneous regression of a large hepatocellular carcinoma with skull metastasis. J Gastroenterol.Hepatol. 2005;20(3):488-492.
Park, I. H., Chung, S. K., Lee, K. B., et al. An antioxidant hispidin from the mycelial cultures of Phellinus linteus. Arch.Pharm.Res 2004;27(6):615-618.
Shibata, Y., Kashiwagi, B., Arai, S., et al. Administration of extract of mushroom Phellinus linteus induces prostate enlargement with increase in stromal component in experimentally developed rat model of benign prostatic hyperplasia. Urology 2005;66(2):455-460.
Song, Y. S., Kim, S. H., Sa, J. H., et al. Anti-angiogenic, antioxidant and xanthine oxidase inhibition activities of the mushroom Phellinus linteus. J Ethnopharmacol. 2003;88(1):113-116.
Zhu, T., Kim, S. H., and Chen, C. Y. A medicinal mushroom: Phellinus linteus. Curr Med Chem 2008;15(13):1330-1335.