Scutellaire du Ba?kal

Related Terms

1-Octen-3-ol, 2',3',5,7-tetrahydroxy flavone, 2',5,6',7-tetrahydroxyflavanonol (THF), 3,7,11,15-tetramethyl-2-hexadecen-1-ol (7.8%), 5,6,7,3',4'-pentahydroxy flavanone-7-O-glucuronide, 5,6,7-trimethylbaicalein, 5,7,2',6'-tetrahydroxyflavone, 5,7,2'-trihydroxyflavone, 6,7-di-O-nicotinoylscutebarbatine G, 6-O-(2-carbonyl-3-methylbutanoyl)scutehenanine A, 6-O-acetylscutehenanine A, 6-O-methyl-baicalin-7-O-beta-glucopyranuronoside, 6-O-nicotinoyl-7-O-acetylscutebarbatine G, 6-O-nicotinoylscutebarbatine G, (6S,9R)6-hydroxy-4,4,7a-trimethyl-5,6,7,7a-tetrahydro-1-benzofuran-2(4H)-one, 7-D-glucuronic acid-5,6-dihydroxy-flavone, (11E)-6alpha-acetoxy-7beta,8beta-dihydroxy-ent-clerodan-3,11,13-trien-15,16-olide (6-acetoxybarbatin C, 2), (13R)-6alpha,7beta-dihydroxy-8beta,13-epoxy-11beta-nicotinyloxy-ent-clerodan-3-en-15,16-olide (scutelinquanine D, 1), amino acids, Antoksyd S (C/E/XXI), Antoxid, apigenin, baicalein, baicalein 6-O-beta-glucopyranuronoside, baicalein 7-D-beta-glucuronate, baicalin, ban-ji-ryun (Korean), banjiryun (Korean), ban-zhi-lian (Chinese), berberine, BZL101, caicalin, carthamidin, Chinese skullcap, chrysin, chrysin-6-C-alpha-L-arabinopyranosyl-8-C-beta-D-glucopyranoside, cinnamate 4-hydroxylase (SbC4H), ethyl-7-O-apigenin-glucuronate, flavonoidglycoside, flavonoids, glucan S b RP-1?, herba Scutellariae barbatae, hexahydrofarnesylacetone, huang-qin, huangqin, isocarthamidin, Lamiaceae (family), luteolin, menthol, minerals, neobaicalein, neoclerodane diterpenoids, neoderodane diterpenoids, organic acids, oroxylin A, oroxylin A-7-O-glucuronide, PC-SPES, phenylalanine ammonia-lyase isoforms (SbPAL1, SbPAL2, and SbAPL3), (S)-2-(4-hydroxyphenyl)-6-methyl-2,3-dihydro-4H-pyran-4-one, SBJ, Scutelleria baicalensis spp., Scutellaria barbata spp., Scutellaria rivularis Wall., scute, scute root, skullcapflavone, trihydroxyflavone, viscidulin III, water-soluble polysaccharides (WSPS'-1, WSPS'-2, and WSPS'-3), wogoninglucuronide, wogonoside.

Background

Baikal skullcap (Scutellaria baicalensis) is a perennial herb native to southern China and throughout Korea. Scutellaria baicalensis is one of approximately 350 Scutellaria species.
Scutellaria baicalensis root is widely used in China as an adjuvant to chemotherapy for lung cancer. It is also commonly used in herbal medicine in Japan. Early studies have found that Scutellaria baicalensis may have anticancer properties. However, there is little clinical evidence. In Western herbalism, Baikal skullcap is also known as an ingredient in PC-SPES, used for prostate cancer.
Traditional uses include antibacterial, anticancer antifungal, anti-inflammatory, antiviral, and neuroprotective. Strong supportive evidence for Scutellaria baicalensis for any use is lacking at this time.
Warning: Scutellaria baicalensis is an ingredient in PC-SPES, which has been recalled from the U.S. market due to possible contamination; PC-SPES should not be used.

Evidence Table

These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. GRADE *
These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. GRADE *


Traditional uses of Baikal skullcap include pain and inflammation. Preliminary research suggests no effect from a product for arthritis containing Baikal skullcap. Further research is required.

 C


Traditional uses of Baikal skullcap include pain and inflammation. Preliminary research suggests no effect from a product for arthritis containing Baikal skullcap. Further research is required.

 C


Traditional uses of Baikal skullcap include brain protection. Preliminary research suggests no effect from a product for minimal brain dysfunction containing Baikal skullcap. Additional research is needed before a conclusion can be drawn.

 C


Traditional uses of Baikal skullcap include brain protection. Preliminary research suggests no effect from a product for minimal brain dysfunction containing Baikal skullcap. Additional research is needed before a conclusion can be drawn.

 C


Traditional uses of Baikal skullcap include cancer treatment. It is a common ingredient in traditional Chinese medicine products. Preliminary research suggests some immunological changes with use in cancer patients. Further research is required.

 C


Traditional uses of Baikal skullcap include cancer treatment. It is a common ingredient in traditional Chinese medicine products. Preliminary research suggests some immunological changes with use in cancer patients. Further research is required.

 C


Traditional uses of Baikal skullcap include liver protection. Preliminary research suggests that some preliminary benefit was associated with a product containing Baikal skullcap with respect to hepatitis B. Additional research is needed before a conclusion can be drawn.

 C


Traditional uses of Baikal skullcap include liver protection. Preliminary research suggests that some preliminary benefit was associated with a product containing Baikal skullcap with respect to hepatitis B. Additional research is needed before a conclusion can be drawn.

 C
* Key to grades

A: Strong scientific evidence for this use
B: Good scientific evidence for this use
C: Unclear scientific evidence for this use
D: Fair scientific evidence for this use (it may not work)
F: Strong scientific evidence against this use (it likley does not work)
* Key to grades

A: Strong scientific evidence for this use
B: Good scientific evidence for this use
C: Unclear scientific evidence for this use
D: Fair scientific evidence for this use (it may not work)
F: Strong scientific evidence against this use (it likley does not work)

Tradition / Theory

The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.

Dosing

Adults (18 years and older)
In general, a typical dose of toasted Baikal skullcap is 6-15 grams.
For cancer (adjunct to chemotherapy), one tablet of Baikal skullcap extract (the amount of extract per tablet is unknown) has been taken by mouth three times daily, starting 5-6 days before chemotherapy and every day thereafter.

Safety

The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.

Interactions

Interactions with Drugs
Baikal skullcap may lower blood sugar levels. Caution is advised when using medications that may also lower blood sugar, including metformin. Patients taking insulin or drugs for diabetes by mouth should be monitored closely by a qualified healthcare professional, including a pharmacist. Medication adjustments may be necessary.
Baikal skullcap may increase the risk of bleeding when taken with drugs that increase the risk of bleeding. Some examples include aspirin, anticoagulants (blood thinners) such as warfarin (Coumadin?) or heparin, antiplatelet drugs such as clopidogrel (Plavix?), and nonsteroidal anti-inflammatory drugs such as ibuprofen (Motrin?, Advil?) or naproxen (Naprosyn?, Aleve?).
Baikal skullcap may cause low blood pressure. Caution is advised in patients taking drugs that lower blood pressure.
Baikal skullcap may interfere with the way the body processes certain drugs using the liver's cytochrome P450 enzyme system. As a result, the levels of these drugs may be increased in the blood and may cause increased effects or potentially serious adverse reactions. Patients using any medications should check the package insert and speak with a qualified healthcare professional, including a pharmacist, about possible interactions.
Baikal skullcap may increase the amount of drowsiness caused by some drugs. Examples include CNS depressants, benzodiazepines such as lorazepam (Ativan?) or diazepam (Valium?), barbiturates such as phenobarbital, narcotics such as codeine, some antidepressants, and alcohol. Caution is advised while driving or operating machinery.
Because Baikal skullcap contains estrogen-like chemicals, the effects of other agents believed to have estrogen-like properties may be altered.
Baikal skullcap also interacts with 5-fluorouracil, Alzheimer's agents, analgesics, antiasthmatics, antibiotics, anticancer drugs, antifungals, antihistamines (allergy medicine), anti-inflammatories, antivirals, cholesterol-lowering drugs (including rosuvastatin), cisplatin, cyclophosphamide, drugs that weaken the immune system, HIV/AIDS drugs, osteoporosis drugs, p-glycoprotein-regulated agents, and weight loss drugs.

Attribution

This information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com).

Bibliography

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