Trumpet satinash

Related Terms

1Beta-hydroxy-3-oxo-lup-20(29)-en-28-oic acid, 3beta,7beta,15alpha-trihydroxy-lup-20(29)-en-28-oic acid, 3beta-hydroxy-lup-20(29)-en-28-oic acid, 3-oxo-11alpha-hydroxy-lup-20(29)-en-28-oic acid, 3-oxo-lup-20(29)-en-28-oic acid, Acmenosperma claviflorum spp., BetA, betulin, betulinic acid, betulinic acid amide, betulinic acid methyl ester, betulinic aldehyde, dehydrocostuslactone, IC9564, lupeol, methyl betulinate, mokko lactone, Myrtaceae (family), NVX-207, oleanolic acid, platanic acid, Syzygium claviflorum, YKFH312.

Background

Trumpet satinash (Syzygium claviflorum) is a member of the Myrtaceae family, which includes 4,500-5,000 species of evergreen trees or shrubs that are found in the Mediterranean region, sub-Saharan Africa, Madagascar, tropical and temperate Asia, Australia, the Pacific Islands, and tropical South America. Betulinic acid is the main constituent of trumpet satinash and is believed to be responsible for its effects.
Betulinic acid may have antitumor activity. Betulinic acid derivatives may have antiretroviral activity. However, there is currently a lack of clinical evidence in support of the use of trumpet satinash for any condition.

Evidence Table

These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. GRADE *
These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. GRADE *
* Key to grades

A: Strong scientific evidence for this use
B: Good scientific evidence for this use
C: Unclear scientific evidence for this use
D: Fair scientific evidence for this use (it may not work)
F: Strong scientific evidence against this use (it likley does not work)
* Key to grades

A: Strong scientific evidence for this use
B: Good scientific evidence for this use
C: Unclear scientific evidence for this use
D: Fair scientific evidence for this use (it may not work)
F: Strong scientific evidence against this use (it likley does not work)

Tradition / Theory

The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.

Dosing

Adults (18 years and older)
There is no proven safe or effective dose for trumpet satinash in adults. Twenty-five milligrams, 50 milligrams, 75 milligrams (with a 150 milligram loading dose), 100 milligrams, 150 milligrams, and 200 milligrams of bevirimat (an anti-HIV drug derived from a betulinic-like compound isolated from trumpet satinash) has been taken by mouth.

Safety

The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.

Interactions

Interactions with Drugs
Trumpet satinash may interact with agents that expel parasitic worms, agents that may damage the liver, anticancer agents, anti-inflammatory agents, antimalarial agents, antiretroviral agents, antiviral agents, or fertility agents.

Attribution

This information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com).

Bibliography

Dang Z, Lai W, Qian K, et al. Betulinic acid derivatives as human immunodeficiency virus type 2 (HIV-2) inhibitors. J Med Chem 2009;52(23):7887-7891.
Drag M, Surowiak P, Drag-Zalesinska M, et al. Comparision of the cytotoxic effects of birch bark extract, betulin and betulinic acid towards human gastric carcinoma and pancreatic carcinoma drug-sensitive and drug-resistant cell lines. Molecules 2009;14(4):1639-1651.
Drag-Zalesinska M, Kulbacka J, Saczko J, et al. Esters of betulin and betulinic acid with amino acids have improved water solubility and are selectively cytotoxic toward cancer cells. Bioorg Med Chem Lett 2009;19(16):4814-4817.
Eksioglu-Demiralp E, Kardas ER, Ozgul S, et al. Betulinic acid protects against ischemia/reperfusion-induced renal damage and inhibits leukocyte apoptosis. Phytother Res 2010;24(3):325-332.
Fulda S. Betulinic acid: a natural product with anticancer activity. Mol Nutr Food Res 2009;53(1):140-146.
Fulda S. Betulinic Acid for cancer treatment and prevention. Int J Mol.Sci 2008;9(6):1096-1107.
Fulda S, Kroemer G. Targeting mitochondrial apoptosis by betulinic acid in human cancers. Drug Discov Today 2009;14(17-18):885-890.
Goff RD, Thorson JS. Enhancing the divergent activities of betulinic acid via neoglycosylation. Org Lett 2009;11(2):461-464.
Karna E, Palka JA. Mechanism of betulinic acid inhibition of collagen biosynthesis in human endometrial adenocarcinoma cells. Neoplasma 2009;56(4):361-366.
Mullauer FB, Kessler JH, Medema JP. Betulinic acid induces cytochrome c release and apoptosis in a Bax/Bak-independent, permeability transition pore dependent fashion. Apoptosis 2009;14(2):191-202.
Nakagawa-Goto K, Yamada K, Taniguchi M, et al. Cancer preventive agents 9. Betulinic acid derivatives as potent cancer chemopreventive agents. Bioorg Med Chem Lett 2009;19(13):3378-3381.
Qian K, Yu D, Chen CH, et al. Anti-AIDS agents. 78. Design, synthesis, metabolic stability assessment, and antiviral evaluation of novel betulinic acid derivatives as potent anti-human immunodeficiency virus (HIV) agents. J Med Chem 2009;52(10):3248-3258.
Theo A, Masebe T, Suzuki, Y, et al. , a traditional South African medicinal plant, contains an anti HIV-1 constituent, betulinic acid. Tohoku J Exp Med 2009;217(2):93-99.
Willmann M, Wacheck V, Buckley J, et al. Characterization of NVX-207, a novel betulinic acid-derived anti-cancer compound. Eur J Clin Invest 2009;39(5):384-394.
Yao D, Li H, Gou Y, et al. Betulinic acid-mediated inhibitory effect on hepatitis B virus by suppression of manganese superoxide dismutase expression. FEBS J 2009;276(9):2599-2614.