Datura

Angel's trumpet/Drug Interactions:

  • Alcohol (ethanol)Alcohol (ethanol): Alcohol causes delirium, respiratory depression, and coma. Datura wrightii may cause additive effects.
  • AmantadineAmantadine: Based on case reports, concomitant use may increase anticholinergic effects and adverse effects (3; 2).
  • AnalgesicsAnalgesics: Emergency room treatment of patients under the influence of Datura wrightii is dangerous. Anesthesia is dangerous to these patients due to the respiratory depression induced by anesthesia. This is additive with the respiratory depression caused by the plant. Several deaths have occurred during anesthesia in these patients.
  • AnticholinergicsAnticholinergics: Based on case reports, concomitant use may increase anticholinergic effects and adverse effects. Drugs include amantadine, atropine, belladonna alkaloids, phenothiazines, scopolamine, and tricyclic antidepressants (3; 2; 4).
  • AnticoagulantsAnticoagulants: Theoretically, Datura wrightii may interact with anticoagulating agents. In laboratory studies, tropane derivatives have been found to inhibit platelet aggregation (21) and inhibit the GABAB receptor (22).
  • Antidepressant agents, monoamine oxidase inhibitors (MAOIs)Antidepressant agents, monoamine oxidase inhibitors (MAOIs): Theoretically, Datura wrightii may interact with MAOIs (3; 2; 4).
  • Antidepressant agents, tricyclic (TCAs)Antidepressant agents, tricyclic (TCAs): Based on case reports, concomitant use may increase anticholinergic effects and adverse effects (3; 2; 4).
  • AntihypertensivesAntihypertensives: There is controversy in the literature. Based on anecdote, angel's trumpet may cause either systemic diastolic hypertension (2; 1) or hypotension (14).
  • Antipsychotic agentsAntipsychotic agents: Datura wrightii preparations theoretically have all the drug interactions of atropine and scopolamine. These agents are known to have additive anticholinergic effects with amantadine and tricyclic antidepressants, increase the effects of atenolol and digoxin, and decrease the antipsychotic effects while increasing the anticholinergic effects of phenothiazines (3; 2; 4).
  • Beta blockersBeta blockers: Datura wrightii preparations theoretically have all the drug interactions of atropine and scopolamine. These agents are known to have additive anticholinergic effects with amantadine and tricyclic antidepressants, increase the effects of atenolol and digoxin, and decrease the antipsychotic effects while increasing the anticholinergic effects of phenothiazines (3; 2; 4).
  • OpiatesOpiates: In laboratory studies, tropane alkaloids isolated from Brugmansia arborea have been noted to reduce morphine withdrawal in a concentration-dependent manner (23).
  • PhenothiazinesPhenothiazines: Based on case reports, concomitant use may increase anticholinergic effects and adverse effects (3; 2).
  • Salicylic acid (aspirin)Salicylic acid (aspirin): In a laboratory study, salicylic acid increased significantly the release of both alkaloids (two- to 12-fold) and it also acted positively on specific production without altering the production profile (24).
  • ScopolamineScopolamine: In a laboratory study, yeast extract incremented the intracellular content of both alkaloids (around three-fold), but particularly increased the release of scopolamine (seven-fold) (24).

    • Angel's trumpet/Herb/Supplement Interactions:

  • Anticholinergic herbsAnticholinergic herbs: Concomitant use may increase anticholinergic effects and adverse effects. Drugs include amantadine, atropine, belladonna alkaloids, phenothiazines, scopolamine, and tricyclic antidepressants (3; 2; 4).
  • Belladonna (or other herbs in the nightshade family)Belladonna (or other herbs in the nightshade family): Concomitant use may increase anticholinergic effects and adverse effects (3; 2).
  • HypotensivesHypotensives: There is controversy in the literature. Based on anecdote, angel's trumpet may cause either systemic diastolic hypertension (2; 1) or hypotension (14).
  • Opiates/poppyOpiates/poppy: Tropane alkaloids isolated from Brugmansia arborea have been noted to reduce morphine withdrawal in a concentration dependent manner (23).
  • ScopolamineScopolamine: Concomitant use may increase anticholinergic effects and adverse effects (3; 2).
  • Willow barkWillow bark: Salicylic acid significantly increased the release of both alkaloids (two- to 12-fold) and it also acted positively on specific production without altering the production profile (24). Theoretically, use of angel's trumpet may interact with willow bark, which has a high salicin content.

    • Angel's trumpet/Food Interactions:

  • AbsorptionAbsorption: Because Datura wrightii decreases gut motility, it may interfere with the absorption of some foods.

    • Angel's trumpet/Lab Interactions:

  • Blood pressureBlood pressure: There is controversy in the literature. Based on anecdote, angel's trumpet may cause either systemic diastolic hypertension (2; 1) or hypotension (14).
  • Coagulation panelCoagulation panel: Tropane derivatives have been found to inhibit platelet aggregation (21).