Datura meteloides

Datura wrightii/Drug Interactions:

  • Alcohol (ethanol)Alcohol (ethanol): Alcohol causes delirium, respiratory depression and coma that may be additive with these effects caused by Datura wrightii.
  • AmantadineAmantadine: Datura wrightii preparations theoretically have all the drug interactions of atropine and scopolamine. These agents are known to have additive anticholinergic effects with amantadine and tricyclic antidepressants, increase the effects of atenolol and digoxin, and decrease the antipsychotic effects while increasing the anticholinergic effects of phenothiazines (3).
  • AnalgesicsAnalgesics: Emergency room treatment of patients under the influence of Datura wrightii is dangerous. Anesthesia is dangerous to these patients due to the respiratory depression induced by anesthesia. This is additive with the respiratory depression caused by the plant. Several deaths have occurred during anesthesia in these patients (1).
  • AnticholinergicsAnticholinergics: Datura wrightii contains atropine and scopolamine as well as other tropane alkaloids. It should not be used internally in patients already receiving atropine, scopolamine or similar anticholinergic drugs.
  • AnticoagulantsAnticoagulants: Theoretically, Datura wrightii may interact with anticoagulating agents. Tropane derivatives have been found to inhibit platelet aggregation (11) and inhibit the GABAB receptor (12).
  • AntidepressantsAntidepressants: Datura wrightii preparations theoretically have all the drug interactions of atropine and scopolamine. These agents are known to have additive anticholinergic effects with amantadine and tricyclic antidepressants, increase the effects of atenolol and digoxin, and decrease the antipsychotic effects while increasing the anticholinergic effects of phenothiazines (3).
  • AntipsychoticsAntipsychotics: Datura wrightii preparations theoretically have all the drug interactions of atropine and scopolamine. These agents are known to have additive anticholinergic effects with amantadine and tricyclic antidepressants, increase the effects of atenolol and digoxin, and decrease the antipsychotic effects while increasing the anticholinergic effects of phenothiazines (3).
  • Beta-blockersBeta-blockers: Datura wrightii preparations theoretically have all the drug interactions of atropine and scopolamine. These agents are known to have additive anticholinergic effects with amantadine and tricyclic antidepressants, increase the effects of atenolol and digoxin, and decrease the antipsychotic effects while increasing the anticholinergic effects of phenothiazines (3).
  • Monoamine oxidase inhibitors (MAOIs) Monoamine oxidase inhibitors (MAOIs): Theoretically, Datura wrightii may interact with MAOIs. Tropane derivatives have been found to inhibit platelet aggregation (11) and inhibit the GABAB receptor (12).

    • Datura wrightii/Herb/Supplement Interactions:

  • AnticholinergicsAnticholinergics: Datura wrightii theoretically may increases the effects of Atropa belladona and other herbs containing anticholinergics.
  • Anticoagulant herbs and supplementsAnticoagulant herbs and supplements: Theoretically, Datura wrightii may interact with anticoagulating agents. Tropane derivatives have been found to inhibit platelet aggregation (11) and inhibit the GABAB receptor (12).
  • FoxgloveFoxglove: Theoretically may increase the effects of Digitalis preparations.
  • Monoamine oxidase inhibitors (MAOIs)Monoamine oxidase inhibitors (MAOIs): Theoretically, Datura wrightii may interact with herbs that have MAOI activity. Tropane derivatives have been found to inhibit platelet aggregation (11) and inhibit the GABAB receptor (12).

    • Datura wrightii/Food Interactions:

  • AbsorptionAbsorption: Because Datura wrightii decreases gut motility, it may interfere with the absorption of some foods.