Erythroxylum vacciniifolium

Catuaba/Drug Interactions:

  • AntibioticsAntibiotics: According to animal and laboratory evidence, catuaba extracts from Erythroxylum catuaba Arr. Cam. and Trichilia catigua exhibited antibacterial activity against E. coli,Staphylococcus aureus (6), and Bacillus (5).
  • Antidepressants, monoamine oxidase inhibitors (MAOIs)Antidepressants, monoamine oxidase inhibitors (MAOIs): In animal research, catuaba extracts from Trichilia catigua possessed antidepressant activity, which was reversed by chlorpromazine and haloperidol, but not by pimozide, ketanserin, spiroxatrine, or p-chlorophenylalanine (8). In a study in rodents, catuaba extracts from Trichilia catigua exhibited dopamine-like antidepressant activity (8). This study showed that, in vitro, Trichilia catigua extract concentration-dependently inhibited the uptake and increased the release of serotonin and dopamine.
  • Anti-inflammatoriesAnti-inflammatories: In evidence obtained in vitro, catuaba extracts from Trichilia catigua inhibited phospholipase A2 (PLA2) activity (7).
  • AntineoplasticsAntineoplastics: In evidence obtained in vitro, catuaba ethanolacetate extracts from Anemopaegma mirandum protected normal human epithelial keratinocytes from cytotoxicity induced by squalene monohydroperoxide (10). Extracts of Anemopaegma mirandum demonstrated cytoprotective effects against rotenone-induced apoptosis in human neuroblastoma SH-SY5Y cells, as evidenced by an alteration in rotenone-induced changes in cellular morphology, condensation of the cell body, nuclear fragmentation, and condensation into discrete dense chromatin clumps (26).
  • AntiviralsAntivirals: In an in vitro human cell line assay, catuaba extracts inhibited the cytopathic effects of human immunodeficiency virus (HIV) (6).
  • Cardiovascular agentsCardiovascular agents: In evidence obtained in vitro using isolated rabbit hearts,Trichilia catigua extracts alone and in the combination product Catuama? reverted ventricular fibrillation and prolonged intraventricular conduction (15).
  • Erectile dysfunction agentsErectile dysfunction agents: In evidence obtained in vitro, catuaba extracts induced short-lived relaxations in a dose-dependent manner in a rabbit corpus cavernosum (RbCC) model (16).
  • SqualeneSqualene: In in vitro human evidence, catuaba reduced the effects of squalene (10).

    • Catuaba/Herb/Supplement Interactions:

  • AntibacterialsAntibacterials: In animal and laboratory evidence, catuaba extracts from Erythroxylum catuaba Arr. Cam. and Trichilia catigua exhibited antibacterial activity against E. coli,Staphylococcus aureus (6) and Bacillus (5).
  • Antidepressants, monoamine oxidase inhibitors (MAOIs)Antidepressants, monoamine oxidase inhibitors (MAOIs): In animal research, catuaba extracts from Trichilia catigua possessed antidepressant activity, which may be reversed by chlorpromazine and haloperidol, but not by pimozide, ketanserin, spiroxatrine, or p-chlorophenylalanine (8). In a study in rodents, catuaba extracts from Trichilia catigua exhibited dopamine-like antidepressant activity (8). This study showed that, in vitro, Trichilia catigua extract concentration-dependently inhibited the uptake and increased the release of serotonin and dopamine.
  • Anti-inflammatoriesAnti-inflammatories: In evidence obtained in vitro, catuaba extracts from Trichilia catigua inhibited PLA2 activity (7).
  • AntineoplasticsAntineoplastics: In evidence obtained in vitro, catuaba ethanolacetate extracts from Anemopaegma mirandum protected normal human epithelial keratinocytes from cytotoxicity induced by squalene monohydroperoxide (10). Extracts of Anemopaegma mirandum demonstrated cytoprotective effects against rotenone-induced apoptosis in human neuroblastoma SH-SY5Y cells, as evidenced by an alteration in rotenone-induced changes in cellular morphology, condensation of the cell body, nuclear fragmentation, and condensation into discrete dense chromatin clumps (26).
  • AntioxidantsAntioxidants: In laboratory assays, catuaba extracts from Trichilia catigua exhibited antioxidant activity (11; 12; 13).
  • AntiviralsAntivirals: In an in vitro human T cell assay, catuaba extracts from Erythroxylum catuaba Arr. Cam. inhibited the cytopathic effects of HIV (6).
  • Cardiovascular agentsCardiovascular agents: In evidence obtained in vitro in isolated rabbit hearts, Trichilia catigua extracts alone and in the combination product Catuama? reverted ventricular fibrillation and prolonged intraventricular conduction (15).
  • Erectile dysfunction agentsErectile dysfunction agents: In evidence obtained in vitro, catuaba extracts from Trichilia catigua induced short-lived relaxations in a dose-dependent manner in a rabbit corpus cavernosum (RbCC) model (16).

    • Catuaba/Food Interactions:

  • Insufficient available evidence.

    • Catuaba/Lab Interactions:

  • Insufficient available evidence.