Fagopyrum esculentum

Buckwheat/Drug Interactions:

  • AntidiabeticsAntidiabetics: In humans and animals, buckwheat consumption had beneficial effects on blood glucose (24; 25; 26; 27). Also, results from an epidemiological study suggest that consumption of buckwheat seed may be a preventive factor for hyperglycemia (16).
  • AntidiarrhealsAntidiarrheals: Buckwheat is a source of dietary fiber (4) and thus may affect intestinal transit time.
  • AntihypertensivesAntihypertensives: In a case report involving an individual allergic to buckwheat, buckwheat ingestion in crepes resulted in hypotension (28). Also, results from an epidemiological study suggest that consumption of buckwheat seed may be a preventive factor for hypertension (16).
  • AntilipemicsAntilipemics: In humans, buckwheat flour increased or had no effect on HDL cholesterol levels (29; 30). Also, results from epidemiological studies suggest that consumption of buckwheat seed may be a preventive factor for dyslipidemia (16; 7).
  • AntineoplasticsAntineoplastics: Proteinase inhibitors from buckwheat suppressed the growth of T cell acute lymphoblastic leukemia cells in vitro (10). Also in vitro, tartary buckwheat flavonoid induced HL-60 leukemic cell apoptosis (11; 97).
  • DiureticsDiuretics: In a clinical trial, buckwheat prevented an increase in leg volume in individuals with chronic venous insufficiency (8).
  • PhotosensitizersPhotosensitizers: Buckwheat contains napthadianthrone compounds, structurally similar to hypericin (31). These compounds are considered photosensitizing.

    • Buckwheat/Herb/Supplement Interactions:

  • AntidiarrhealsAntidiarrheals: Buckwheat is a source of dietary fiber (4) and thus may affect intestinal transit time.
  • AntilipemicsAntilipemics: In humans, buckwheat flour increased or had no effect on HDL cholesterol levels (29; 30). Also, results from epidemiological studies suggest that consumption of buckwheat seed may be a preventive factor for dyslipidemia (16; 7).
  • AntineoplasticsAntineoplastics: Proteinase inhibitors from buckwheat suppressed the growth of T acute lymphoblastic leukemia cells in vitro (10). Also in vitro, tartary buckwheat flavonoid induced HL-60 leukemic cell apoptosis (11; 97).
  • DiureticsDiuretics: In a clinical trial, buckwheat prevented an increase in leg volume in individuals with chronic venous insufficiency (8).
  • FlavonoidsFlavonoids: Buckwheat is a source of flavonoids, such as quercetin and rutin (98; 4; 99).
  • HypoglycemicsHypoglycemics: In humans and animals, buckwheat consumption had beneficial effects on blood glucose (24; 25; 26; 27). Also, results from an epidemiological study suggest that consumption of buckwheat seed may be a preventive factor for hyperglycemia (16).
  • HypotensivesHypotensives: In a case report involving an individual allergic to buckwheat, buckwheat ingestion in crepes resulted in hypotension (28). Also, results from an epidemiological study suggest that consumption of buckwheat seed may be a preventive factor for hypertension (16).
  • PhotosensitizersPhotosensitizers: Buckwheat contains napthadianthrone compounds, structurally similar to hypericin (31). These compounds are considered photosensitizing.
  • Rutin-containing herbsRutin-containing herbs: Buckwheat is a source of rutin and other flavonoids (98; 4; 99).
  • St. John's wortSt. John's wort: Buckwheat contains napthadianthrone compounds, structurally similar to hypericin (31).
  • Vitamin CVitamin C: Traditionally, rutin is thought to be better absorbed when used n conjunction with vitamin C. It may be possible that the rutin from buckwheat is better absorbed when taken with vitamin C.

    • Buckwheat/Food Interactions:

  • FlavonoidsFlavonoids: Buckwheat is a source of flavonoids, such as quercetin and rutin (98; 4; 99).
  • Hypocholesterolemic dietsHypocholesterolemic diets: In humans, buckwheat flour increased or had no effect on HDL cholesterol levels (29; 30). Also, results from epidemiological studies suggest that consumption of buckwheat seed may be a preventive factor for dyslipidemia (16; 7).
  • Hypoglycemic dietsHypoglycemic diets: In humans and animals, buckwheat consumption had beneficial effects on blood glucose (24; 25; 26; 27). Also, results from an epidemiological study suggest that consumption of buckwheat seed may be a preventive factor for hyperglycemia (16).
  • Hypotensive dietsHypotensive diets: In a case report involving an individual allergic to buckwheat, buckwheat ingestion in crepes resulted in hypotension (28). Also, results from an epidemiological study suggest that consumption of buckwheat seed may be a preventive factor for hypertension (16).
  • Rutin-containing foodsRutin-containing foods: Buckwheat is a source of rutin and other flavonoids (98; 4; 99).
  • Soy proteinSoy protein: Foods containing soy and buckwheat were investigated for effects on glycemia and triglyceridemia in diabetic patients (14).
  • Vitamin C-containing foodsVitamin C-containing foods: Traditionally, rutin is thought to be better absorbed when used in conjunction with vitamin C. It may be possible that the rutin from buckwheat is better absorbed when taken with vitamin C.

    • Buckwheat/Lab Interactions:

  • Blood glucoseBlood glucose: In humans and animals, buckwheat consumption had beneficial effects on blood glucose (24; 25; 26; 27). Also, results from an epidemiological study suggest that consumption of buckwheat seed may be a preventive factor for hyperglycemia (16).
  • Blood pressureBlood pressure: In a case report involving an individual allergic to buckwheat, buckwheat ingestion in crepes resulted in hypotension (28). Also, results from an epidemiological study suggest that consumption of buckwheat seed may be a preventive factor for hypertension (16).
  • Lipid profileLipid profile: In humans, buckwheat flour increased or had no effect on HDL cholesterol levels (29; 30). Also, results from epidemiological studies suggest that consumption of buckwheat seed may be a preventive factor for dyslipidemia (16; 7).