Guarumo

Guarumo/Drug Interactions:

  • AnalgesicsAnalgesics: In animal study, aqueous extract of Cecropia obtusifolia has been shown to exhibit analgesic activity (6). Theoretically, concurrent use of guarumo with analgesics may have additive effects.
  • Antidiabetic agentsAntidiabetic agents: Human, animal, and in vitro have found Cecropia obtusifolia to have blood sugar-lowering effects likely due to the chlorogenic acid constituent (2; 3; 9; 10; 11). Theoretically, concurrent use of guarumo and antidiabetic agents may lower blood glucose levels and increase the risk of hypoglycemia.
  • AntihypertensivesAntihypertensives: Based on animal study, the aqueous leaf extract of Cecropia obtusifolia may exhibit antihypertensive effects (7; 8; 4). In vitro experimentation has also indicated that the ethanolic extract of several species of Cecropia (glaziovii, hololeuca, and pachystachyae) may inhibit angiotensin-converting enzyme (ACE) and therefore decrease high blood pressure (12). Theoretically, concurrent use of guarumo and antihypertensive agents may increase the risk of hypotension.
  • Anti-inflammatory agentsAnti-inflammatory agents: In animal study, aqueous extract of Cecropia obtusifolia showed a topical and systemic anti-inflammatory effect (6). Theoretically, concurrent use of guarumo with anti-inflammatory agents may have additive effects.
  • Antilipemic agentsAntilipemic agents: Based on clinical study, Cecropia obtusifolia may decrease triglycerides and cholesterol levels (2). However, no changes were noted in another study (3). Theoretically, concurrent use of guarumo and antilipemic agents may have additive lipid-lowering effects.
  • CNS depressantsCNS depressants: In animal study, aqueous extract of Cecropia obtusifolia depressed the central nervous system (6). Theoretically, concurrent use of Cecropia obtusifolia may cause additive effects.
  • DiureticsDiuretics: Animal study indicates that aqueous leaf extract of Cecropia obtusifolia may have a diuretic effect (5). Theoretically concurrent use of Cecropia obtusifolia with diuretics may have additive effects and increases the risk of electrolyte imbalances.
  • Skeletal muscle relaxantsSkeletal muscle relaxants: In animal study, aqueous extract of Cecropia obtusifolia had muscle relaxant activity (6). Theoretically, concurrent use of Cecropia obtusifolia may cause additive effects.

    • Guarumo/Herb/Supplement Interactions:

  • AnalgesicsAnalgesics: Based on animal study, aqueous extract of Cecropia obtusifolia has been shown to exhibit analgesic activity (6). Theoretically, concurrent use of guarumo with analgesics may have additive effects.
  • Anti-inflammatory herbsAnti-inflammatory herbs: In animal study, aqueous extract of Cecropia obtusifolia showed a topical and systemic anti-inflammatory effect (6). Theoretically, concurrent use of guarumo with anti-inflammatory agents may have additive effects.
  • AntilipemicsAntilipemics: Based on clinical study, Cecropia obtusifolia may decrease triglycerides and cholesterol levels (2). However, no changes were noted in another study (3). Theoretically, concurrent use of guarumo and antilipemic agents may have additive lipid-lowering effects.
  • DiureticsDiuretics: Animal study indicates that aqueous leaf extract of Cecropia obtusifolia may have a diuretic effect (5). Theoretically concurrent use of Cecropia obtusifolia with diuretics may have additive effects and increases the risk of electrolyte imbalances.
  • HypoglycemicsHypoglycemics: Human, animal, and in vitro have found Cecropia obtusifolia to have blood sugar-lowering effects, likely due to the chlorogenic acid constituent (2; 3; 9; 10; 11). Theoretically, concurrent use of guarumo and antidiabetic agents may lower blood glucose levels and increase the risk of hypoglycemia.
  • HypotensivesHypotensives: Based on animal study, the aqueous leaf extract of Cecropia obtusifolia may exhibit antihypertensive effects (7; 8; 4). In vitro experimentation has also indicated that the ethanolic extract of several species of Cecropia (glaziovii, hololeuca, and pachystachyae) may inhibit angiotensin-converting enzyme (ACE) and therefore decrease high blood pressure (12). Theoretically, concurrent use of guarumo and antihypertensive agents may increase the risk of hypotension.
  • SedativesSedatives: In animal study, aqueous extract of Cecropia obtusifolia depressed the central nervous system (6). Theoretically, concurrent use of Cecropia obtusifolia may cause additive sedative effects.

    • Guarumo/Food Interactions:

  • Insufficient available evidence.

    • Guarumo/Lab Interactions:

  • Blood glucoseBlood glucose: Human, animal, and in vitro studies have found Cecropia obtusifolia to lower blood glucose (2; 3; 9; 10; 11).
  • Blood pressureBlood pressure: In animal study, an intravenous ethanol extract of Cecropia obtusifolia reduced blood pressure approximately 45 minutes after injection (4)
  • ElectrolytesElectrolytes: Animal study indicates that aqueous leaf extract of Cecropia obtusifolia may have a diuretic effect (5) and theoretically may alter electrolytes.
  • Heart rateHeart rate: In animal study, an intravenous ethanol extract of Cecropia obtusifolia increased heart rate approximately 45 minutes after injection (4).
  • Lipid profileLipid profile: Based on clinical study, Cecropia obtusifolia may decrease triglycerides and cholesterol levels (2). However, no changes were noted in another study (3).