Harpagophytum procumbens

Devil's claw/Drug Interactions:

  • AnalgesicsAnalgesics: Based on in vitro, animal and human study, devil's claw may have analgesic properties (1; 6; 3; 23; 24; 25; 26; 27; 28; 29).
  • AntacidsAntacids: Anecdotal reports note that devil's claw may increase stomach pH, and therefore may interfere with the effects of antacids, sucralfate, H2-antagonists or proton pump inhibitors.
  • Antiarrhythmic agentsAntiarrhythmic agents: Based on animal study, devil's claw may protect against cardiac arrhythmias (21; 22), decrease heart rate (21), or cause mild positive inotropic effects in lower doses and marked negative inotropic effects in higher doses (21).
  • Anticoagulants and antiplateletsAnticoagulants and antiplatelets: One case of purpura has been reported in a patient taking warfarin (Coumadin?) with devil's claw (30), although the details are limited, and therefore the evidence is inconclusive (37).
  • Antidiabetic agentsAntidiabetic agents: Based on anecdotal reports, devil's claw lowers serum glucose levels.
  • AntidiarrhealsAntidiarrheals: Based on one clinical study of patients with osteoarthritis, devil's claw (Harpadol?) may cause diarrhea (25).
  • Antigout agentsAntigout agents: Anecdotal reports have indicated that devil's claw may reduce high uric acid concentrations, which are often associated with gout.
  • Anti inflammatory agentsAnti inflammatory agents: Based on in vitro, animal, and human studies, devil's claw may have anti inflammatory activity (1; 2; 3; 4; 5; 6; 7; 8; 9; 10; 11; 12; 13; 14; 15; 16; 17; 18).
  • Antilipemic agentsAntilipemic agents: There are anecdotal reports that devil's claw may reduce cholesterol concentrations.
  • Antimalarial agentsAntimalarial agents: Based on in vitro study, devil's claw may have antiplasmodial activity (35).
  • Cardiovascular agentsCardiovascular agents: Animal experiments have reported a protective effect against cardiac arrhythmias (21; 22). Use with antiarrhythmic agents may result in additive effects. In rats, devil's claw decreased heart rate (21). Therefore, use with other agents with similar properties may result in additive effects. In rabbits, devil's claw (harpagoside constituent) caused mild positive inotropic effects in lower doses and marked negative inotropic effects in higher doses. The hapagide component only resulted in negative inotropy (21), and therefore may diminish or potentiate the effects of other inotropic agents.
  • InotropesInotropes: In rabbits, devil's claw (harpagoside constituent) caused mild positive inotropic effects in lower doses and marked negative inotropic effects in higher doses. The hapagide component only resulted in negative inotropy (21), and therefore may diminish or potentiate the effects of other inotropic agents.
  • Lipoxygenase inhibitorsLipoxygenase inhibitors: Based on in vitro studies, some devil's claw extracts may inhibit 5-lipoxygenase biosynthesis (33).

    • Devil's claw/Herb/Supplement Interactions:

  • AnalgesicsAnalgesics: Based on in vitro, animal and human studies, devil's claw may have analgesic properties (1; 6; 3; 23; 24; 25; 26; 27; 28; 29).
  • AntacidsAntacids: Anecdotal reports note that devil's claw may increase stomach pH, and therefore may interfere with the effects of antacids, sucralfate, H2-antagonists or proton pump inhibitors.
  • AntiarrhythmicsAntiarrhythmics: Based on animal study, devil's claw may protect against cardiac arrhythmias (21; 22), decrease heart rate (21), or cause mild positive inotropic effects in lower doses and marked negative inotropic effects in higher doses (21).
  • Anticoagulants and antiplateletsAnticoagulants and antiplatelets: One case of purpura has been reported in a patient taking warfarin (Coumadin?) with devil's claw (30), although the details are limited, and therefore the evidence is inconclusive (37).
  • AntidiarrhealsAntidiarrheals: Based on one clinical study of patients with osteoarthritis, devil's claw (Harpadol?) may cause diarrhea (25).
  • HypoglycemicsHypoglycemics: Based on anecdotal reports, devil's claw lower serum glucose levels.
  • HyperglycemicsHyperglycemics: Based on anecdotal reports, devil's claw lower serum glucose levels.
  • Antigout herbs and supplementsAntigout herbs and supplements: Anecdotal reports have indicated that devil's claw may reduce high uric acid concentration, which are often associated with gout.
  • Anti inflammatory herbsAnti inflammatory herbs: Based on in vitro, animal, and human study, devil's claw may have anti inflammatory activity (1; 2; 3; 4; 5; 6; 7; 8; 9; 10; 11; 12; 13; 14; 15; 16; 17; 18).
  • AntilipemicsAntilipemics: There are anecdotal reports that devil's claw may reduce cholesterol concentrations.
  • AntioxidantsAntioxidants: Based on animal studies, devil's claw may have antioxidant activity (31; 32).
  • Antimalarial herbs and supplementsAntimalarial herbs and supplements: Based on in vitro study, devil's claw may have antiplasmodial activity (35).
  • Cardioactive herbsCardioactive herbs: Animal experiments have reported a protective effect against cardiac arrhythmias (21; 22). Use with antiarrhythmic agents may result in additive effects. In rats, devil's claw decreased heart rate (21). Therefore, use with other agents with similar properties may result in additive effects. In rabbits, devil's claw (harpagoside constituent) caused mild positive inotropic effects in lower doses and marked negative inotropic effects in higher doses. The hapagide component only resulted in negative inotropy (21), and therefore may diminish or potentiate the effects of other inotropic agents.
  • Inotropic herbsInotropic herbs: In rabbits, devil's claw (harpagoside constituent) caused mild positive inotropic effects in lower doses and marked negative inotropic effects in higher doses. The hapagide component only resulted in negative inotropy (21), and therefore may diminish or potentiate the effects of other inotropic agents.
  • Lipoxygenase inhibitorsLipoxygenase inhibitors: Based on in vitro studies, some devil's claw extracts may inhibit 5-lipoxygenase biosynthesis (33).

    • Devil's claw/Food Interactions:

  • Insufficient available evidence.

    • Devil's claw/Lab Interactions:

  • Coagulation panelCoagulation panel: One case of purpura has been reported in a patient taking warfarin (Coumadin?) with devil's claw (30), although the details are limited, and therefore the evidence is inconclusive (37).
  • Lipid profileLipid profile: There are anecdotal reports that devil's claw may reduce cholesterol concentrations.
  • Serum glucose levelsSerum glucose levels: Based on anecdotal reports, devil's claw lower serum glucose levels.
  • Uric acidUric acid: Anecdotal reports have indicated that devil's claw may reduce high uric acid concentrations.