Helleborus niger

Black hellebore/Drug Interactions:

  • Cardiac glycosidesCardiac glycosides: Black hellebore contains cardiac glycosides, which have a similar action as foxglove (Digitalis spp.), a cardiac stimulant.
  • DigoxinDigoxin: Black hellebore contains cardiac glycosides, which have a similar action as foxglove (Digitalis spp.), a cardiac stimulant.
  • Diuretics, potassium depletingDiuretics, potassium depleting: Black hellebore contains cardiac glycosides; theoretically, concomitant use of black hellebore and potassium depleting diuretics may lead to decreased potassium levels.
  • Gastrointestinal agentsGastrointestinal agents: According to secondary sources, black hellebore may cause gastrointestinal irritation.
  • NarcoticsNarcotics: The root and leaves of various species of Helleborus contain the glucoside helleborin, a narcotic poison.
  • QuinineQuinine: Black hellebore contains cardiac glycosides, which theoretically may interact with quinine, a cardiac depressant.
  • Stimulant laxativesStimulant laxatives: According to secondary sources, black hellebore may cause gastrointestinal irritation.

    • Black hellebore/Herb/Supplement Interactions:

  • Cardiac glycosidesCardiac glycosides: Black hellebore contains cardiac glycosides, which have a similar action as foxglove (Digitalis spp.), a cardiac stimulant.
  • Cinchona (Cinchona pubescens), quinineCinchona (Cinchona pubescens), quinine: Black hellebore contains cardiac glycosides, which theoretically may interact with quinine, a cardiac depressant.
  • Diuretics, potassium depletingDiuretics, potassium depleting: Black hellebore contains cardiac glycosides; theoretically, concomitant use of black hellebore and potassium depleting diuretics may lead to decreased potassium levels.
  • Foxglove (Digitalis spp.), digoxinFoxglove (Digitalis spp.), digoxin: Black hellebore contains cardiac glycosides, which have a similar action as foxglove (Digitalis spp.), a cardiac stimulant.
  • Gastrointestinal agentsGastrointestinal agents: According to secondary sources, black hellebore may cause gastrointestinal irritation.
  • HorsetailHorsetail: Both black hellebore and horsetail contain cardiac glycosides, which may cause potassium depletion.
  • LicoriceLicorice: Both black hellebore and licorice contain cardiac glycosides, which may cause potassium depletion.
  • Stimulant laxativesStimulant laxatives: According to secondary sources, black hellebore may cause gastrointestinal irritation.

    • Black hellebore/Food Interactions:

  • Insufficient evidence available.

    • Black hellebore/Lab Interactions:

  • Cardiac function testsCardiac function tests: Black hellebore contains cardiac glycosides, which have a similar action as foxglove (Digitalis spp.), a cardiac stimulant. Therefore, black hellebore may interfere with tests to measure cardiac function.
  • Gastrointestinal function testsGastrointestinal function tests: According to secondary sources, black hellebore may cause gastrointestinal irritation. Therefore, black hellebore may interfere with tests to measure gastrointestinal function.