Hemlock

Hemlock/Drug Interactions:

  • NoteNote: Hemlock is poisonous when taken internally, except when diluted into homeopathic preparations. Numerous interactions are theoretically possible.
  • Cardiovascular agentsCardiovascular agents: The general symptoms of hemlock poisoning include a slow and weak pulse becoming rapid at a later stage (1).
  • Gastrointestinal agentsGastrointestinal agents: The general symptoms of hemlock poisoning include vomiting, salivation, and nausea (1).
  • Nephrotoxic agentsNephrotoxic agents: Clinicians have observed non-neurological manifestations of hemlock poisoning, including rhabdomyolysis, myoglobinuria, acute tubular necrosis, and acute renal failure (11; 12; 13).
  • Neurologic agentsNeurologic agents: Hemlock poisoning affects the central nervous system, causing CNS stimulation followed by depression, including paralysis of motor nerve endings (1; 25).

    • Hemlock/Herb/Supplement Interactions:

  • NoteNote: Hemlock is poisonous when taken internally, except when diluted into homeopathic preparations. Numerous interactions are theoretically possible.
  • Cardiovascular herbs and supplementsCardiovascular herbs and supplements: The general symptoms of hemlock poisoning include a slow and weak pulse becoming rapid at a later stage (1).
  • Gastrointestinal herbs and supplementsGastrointestinal herbs and supplements: The general symptoms of hemlock poisoning include vomiting, salivation, and nausea (1).
  • Nephrotoxic herbs and supplementsNephrotoxic herbs and supplements: Clinicians have observed non-neurological manifestations of hemlock poisoning, including rhabdomyolysis, myoglobinuria, acute tubular necrosis, and acute renal failure (11; 12; 13).
  • Neurologic herbs and supplementsNeurologic herbs and supplements: Hemlock poisoning affects the central nervous system, causing CNS stimulation followed by depression, including paralysis of motor nerve endings (1; 25).

    • Hemlock/Food Interactions:

  • Insufficient available data.

    • Hemlock/Lab Interactions:

  • NoteNote: Hemlock is poisonous when taken internally, except when diluted into homeopathic preparations. Numerous interactions are theoretically possible.
  • Creatine phosphokinase (CPK)Creatine phosphokinase (CPK): Rhabdomyolysis has been reported in patients with acute hemlock intoxication (24; 10; 11; 12; 13), which may result in very high blood levels of CPK.
  • HemoglobinHemoglobin: Rhabdomyolysis has been reported in patients with acute hemlock intoxication (24; 10; 11; 12; 13), which may result in a positive test for hemoglobin in the urine.
  • Kidney function testsKidney function tests: Several authors have reported on cases of acute renal failure as a result of hemlock poisoning (24; 10; 11; 12; 13). However, predonation lab values were "unremarkable" in a victim of hemlock poisoning whose organs (kidney, liver, and pancreas) were used in transplants (6).
  • Myoglobin (serum)Myoglobin (serum): Rhabdomyolysis has been reported in patients with acute hemlock intoxication (24; 10; 11; 12; 13), which may result in a positive test for myoglobin in the blood.
  • Myoglobin (urine)Myoglobin (urine): Rhabdomyolysis has been reported in patients with acute hemlock intoxication (24; 10; 11; 12; 13), which may result in a positive test for myoglobin in the urine. Myoglobinuria has been reported in patients with rhabdomyolysis from hemlock poisoning (10).
  • PotassiumPotassium: Rhabdomyolysis has been reported in patients with acute hemlock intoxication (24; 10; 11; 12; 13), which may result in very high blood levels of potassium.