Histidyl-proline Diketopiperazine

Cyclo(His-Pro)/Drug Interactions:

  • AlcoholAlcohol: In animal research, oral cyclo(His-Pro) in certain concentrations decreased consumption of a solution of ethanol in water (3).
  • AmphetamineAmphetamine: In an animal study, cyclo(His-Pro) potentiated amphetamine in its production of stereotypy (constant repetition of certain meaningless gestures or movements) (9).
  • Antidiabetic agentsAntidiabetic agents: In animal studies in rats and mice with diabetes, cyclo(His-Pro) plus zinc decreased blood glucose concentrations (1; 6; 2).
  • Antineoplastic agentsAntineoplastic agents: In the cell line PC-12, cyclo(His-Pro) resulted in a decrease in apoptosis (8).
  • BarbituratesBarbiturates: In an animal study, intracerebroventricular cyclo(His-Pro) prolonged narcosis from pentobarbital (10).
  • KetamineKetamine: Based on research, cyclo(His-Pro) antagonized ketamine's anesthetic effect (11).

    • Cyclo(His-Pro)/Herb/Supplement Interactions:

  • AntineoplasticsAntineoplastics: In the cell line PC-12, cyclo(His-Pro) resulted in a decrease in apoptosis (8).
  • AntioxidantsAntioxidants: Cyclo(His-Pro) may act as an antioxidant in vitro (4).
  • HypoglycemicsHypoglycemics: In animal studies in rats and mice with diabetes, cyclo(His-Pro) plus zinc decreased blood glucose concentrations (1; 6; 2).
  • ZincZinc: Based on secondary sources, cyclo(His-Pro) may improve the absorption of zinc from the intestines.

    • Cyclo(His-Pro)/Food Interactions:

  • Insufficient available evidence.

    • Cyclo(His-Pro)/Lab Interactions:

  • Blood glucoseBlood glucose: In animal studies in rats and mice with diabetes, cyclo(His-Pro) plus zinc decreased blood glucose concentrations (1; 6; 2).