Horseradish

Horseradish/Drug Interactions:

  • AntibioticsAntibiotics: Based on several early in vitro studies and one clinical trial, horseradish may have antibiotic activity (14; 15; 16; 11; 22).
  • Anticoagulants and antiplateletsAnticoagulants and antiplatelets: Based on an animal study using intravenous horseradish peroxidase, intravenous horseradish may stimulate synthesis of arachidonic acid metabolites (17).
  • AntihypertensivesAntihypertensives: Based on animal study, horseradish in medicinal amounts may have hypotensive activity (18; 17).
  • Anti inflammatory agentsAnti inflammatory agents: Based on an in vitro study, horseradish may inhibit COX-1 enzymes (1; 2).
  • Antineoplastic agentsAntineoplastic agents: Based on in vitro and animal studies, horseradish may have antineoplastic activity (3; 4; 5; 6; 7; 8; 9; 1; 2; 10; 11; 12; 13).
  • AntioxidantsAntioxidants: Based on in vitro study, horseradish root may have oxidative activity (11; 23).
  • Antithyroid agentsAntithyroid agents: Based on in vitro evidence, medicinal amounts of horseradish may interact with thyroid medications (20).
  • DiureticsDiuretics: Based on traditional use, horseradish may have strong diuretic effects.
  • Indole-3-acetic acidIndole-3-acetic acid: Based on numerous in vitro studies, horseradish peroxidase may activate indole-3-acetic acid (3; 4; 5; 6; 7; 8).
  • LevothyroxineLevothyroxine: Based on in vitro evidence, medicinal amounts of horseradish may interact with thyroid medications (20).

    • Horseradish/Herb/Supplement Interactions:

  • AntibacterialsAntibacterials: Based on several early in vitro studies and one clinical trial, horseradish may have antibiotic activity (14; 15; 16; 11; 22).
  • Anticoagulants and antiplateletsAnticoagulants and antiplatelets: Based on an animal study using intravenous horseradish peroxidase, intravenous horseradish may stimulate synthesis of arachidonic acid metabolites (17).
  • Anti inflammatory herbsAnti inflammatory herbs: Based on an in vitro study, horseradish may inhibit COX-1 enzymes (1; 2).
  • AntineoplasticsAntineoplastics: Based on in vitro and animal studies, horseradish may have antineoplastic activity (3; 4; 5; 6; 7; 8; 9; 1; 2; 10; 11; 12; 13).
  • AntioxidantsAntioxidants: Based on in vitro study, horseradish root may have oxidative activity (11; 23).
  • DiureticsDiuretics: Based on traditional use, horseradish may have strong diuretic effects.
  • HypotensivesHypotensives: Based on animal study, horseradish in medicinal amounts may have hypotensive activity (18; 17).
  • Indole-3-acetic acidIndole-3-acetic acid: Based on numerous in vitro studies, horseradish peroxidase may activate indole-3-acetic acid (3; 4; 5; 6; 7; 8).
  • Tannin-containing herbsTannin-containing herbs: According to secondary sources, horseradish contains tannins, which may have additive effects when taken with other tannin-containing herbs.
  • Thyroid agentsThyroid agents: Based on in vitro evidence, medicinal amounts of horseradish may interact with thyroid medications (20).
  • Vitamin CVitamin C: According to herbal textbooks, horseradish contains a high level of vitamin C.

    • Horseradish /Food Interactions:

  • Insufficient available evidence.

    • Horseradish /Lab Interactions:

  • Blood pressureBlood pressure: Based on an animal study, horseradish in medicinal amounts may have hypotensive activity (18; 17).
  • Blood cultureBlood culture: Based on several early in vitro studies and one clinical trial, horseradish may have antibiotic activity (14; 15; 16; 11; 22).
  • Coagulation panelCoagulation panel: Based on an animal study using intravenous horseradish peroxidase, intravenous horseradish may stimulate synthesis of arachidonic acid metabolites (17).
  • Thyroid panelThyroid panel: Based on in vitro evidence, medicinal amounts of horseradish may interact with thyroid medications (20).