Inonotus obliquus

Chaga/Drug Interactions:

  • Anticoagulants and antiplateletsAnticoagulants and antiplatelets: In vitro and in vivo, an ethanol extract from chaga has been shown to inhibit platelet aggregation (15).
  • AntidiabeticsAntidiabetics: In vivo, dry matter of culture broth (DMCB) of chaga achieved euglycemia in chaga- and glibenclamide-treated mice after glucose loading, and decreased blood glucose levels and increased insulin levels and hepatic glycogen in alloxan-induced diabetic mice (7). In addition, histological morphology examination showed that the DMCB restored damaged pancreas tissues in mice with diabetes mellitus.
  • Anti-inflammatoriesAnti-inflammatories: In vivo, a methanol extract of chaga reduced acute paw edema induced by carrageenin in rats, and showed analgesic activity (6).
  • AntilipemicsAntilipemics: In vivo, treatment with chaga decreased serum contents of free fatty acid (FFA), total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C), and increased high-density lipoprotein cholesterol (HDL-C) in diabetic mice (7).
  • AntineoplasticsAntineoplastics: In mice, chaga extract prolonged the survival rate and had an effect on various types of cancer (16; 17). In vitro, chaga extracts had antitumor (18; 19; 20; 21; 22; 23; 24), antimutagenic (1), antiproliferative (2), apoptotic (13), and antimitotic activities (25) against various types of cancer, including inhibiting growth of tumor cells (26; 27; 13); decreasing cell protein amount (27), mitotic index value (26; 27), and enzyme activities (27); and increasing the activity of catalase (25).
  • ImmunosuppressantsImmunosuppressants: In vitro, the mycelial endopolysaccharide of chaga has shown enhanced proliferation and polyclonal IgM antibody production in B cells; enhanced nitrite production and expression of IL-1beta, IL-6, TNF-alpha, and iNOS in macrophages; and an indirect anticancer effect via immunostimulation (28).

    • Chaga /Herb/Supplement Interactions:

  • Anticoagulants and antiplateletsAnticoagulants and antiplatelets: In vitro and in vivo, an ethanol extract from chaga has been shown to inhibit platelet aggregation (15).
  • AntineoplasticsAntineoplastics: In mice, chaga extract prolonged the survival rate and had an effect on various types of cancer (16; 17). In vitro, chaga extracts had antitumor (18; 19; 20; 21; 22; 23; 24), antimutagenic (1), antiproliferative (2), apoptotic (13), and antimitotic activities (25) against various types of cancer, including inhibiting growth of tumor cells (26; 27; 13); decreasing cell protein amount (27), mitotic index value (26; 27), and enzyme activities (27); and increasing the activity of catalase (25).
  • Anti-inflammatoriesAnti-inflammatories: In vivo, a methanol extract of chaga reduced acute paw edema induced by carrageenin in rats, and showed analgesic activity (6).
  • AntilipemicsAntilipemics: In vivo, treatment with chaga significantly decreased serum contents of free fatty acid (FFA), total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C), and increased high-density lipoprotein cholesterol (HDL-C) in diabetic mice (7).
  • AntioxidantsAntioxidants: In vivo, treatment with chaga significantly increased catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities, and decreased malondialdehyde (MDA) levels in diabetic mice (7). In vitro, supplementation of ethanol-extracted chaga resulted in a significant reduction of H202-induced DNA damage in human lymphocytes (10; 5). Various extracts of chaga have also exhibited antioxidant activity towards numerous free radicals (29; 1; 9; 30; 23) and have shown inhibition of NO production (9).
  • HypoglycemicsHypoglycemics: In vivo studies have shown that the dry matter of culture broth (DMCB) of chaga achieved euglycemia in chaga- and glibenclamide-treated mice, and significantly decreased blood glucose levels and increased insulin levels and hepatic glycogen in alloxan-induced diabetic mice (7). In addition, histological morphology examination showed that the DMCB restored damaged pancreas tissues in mice with diabetes mellitus.
  • ImmunomodulatorsImmunomodulators: In vitro, the mycelial endopolysaccharide of chaga has shown enhanced proliferation and polyclonal IgM antibody production in B cells; enhanced nitrite production and expression of IL-1beta, IL-6, TNF-alpha, and iNOS in macrophages; and an indirect anticancer effect via immunostimulation (28).

    • Chaga/Food Interactions:

  • Insufficient available evidence.

    • Chaga/Lab Interactions:

  • Antioxidant statusAntioxidant status: In vivo studies have shown that treatment with chaga significantly increased catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities, and decreased malondialdehyde (MDA) levels in diabetic mice (7). In vitro supplementation of ethanol-extracted chaga resulted in a significant reduction of H202-induced DNA damage in human lymphocytes (10; 5). Various extracts of chaga have also exhibited antioxidant activity towards numerous free radicals (29; 1; 9; 30; 23) and have shown inhibition of NO production (9).
  • Coagulation panelCoagulation panel: In vitro and in vivo, ethanol extract from chaga has shown inhibition of platelet aggregation (15).
  • GlucoseGlucose: In vivo studies have shown that the dry matter of culture broth of chaga achieved euglycemia in chaga- and glibenclamide-treated mice after 120 minutes of glucose loading, and significantly decreased blood glucose levels and hepatic glycogen in alloxan-induced diabetic mice (7).
  • Immunological markersImmunological markers: In vitro studies have shown that the mycelial endopolysaccharide of chaga has shown enhanced proliferation and polyclonal IgM antibody production in B cells; enhanced nitrite production and expression of IL-1beta, IL-6, TNF-alpha, and iNOS in macrophages; and an indirect anticancer effect via immunostimulation (28).
  • InsulinInsulin: In vivo studies have shown that the dry matter of culture broth of chaga significantly increased insulin levels in alloxan-induced diabetic mice (7).
  • Lipid profileLipid profile: In vivo studies have shown that treatment with chaga significantly decreased serum contents of free fatty acid (FFA), total cholesterol (TC), triglyceride (TG,) and low-density lipoprotein cholesterol (LDL-C), and increased high-density lipoprotein cholesterol (HDL-C) in diabetic mice (7).