Ivy gourd

Coccinia indica/Drug Interactions:

  • AntidiabeticsAntidiabetics: In human and studies, Coccinia indica has been shown to decrease blood sugar levels in humans (5; 4; 6; 7) and to have hypoglycemic effects in animals (9; 10; 14; 8; 16; 2; 1; 11; 13; 12; 15).
  • AntilipemicsAntilipemics: According to animal studies, Coccinia indica may exert hypolipidemic effects (15; 18). Theoretically, concurrent use may have additive effects.

    • Coccinia indica/Herb/Supplement Interactions:

  • AntilipemicsAntilipemics: According to animal studies, Coccinia indica may exert hypolipidemic effects (15; 18). Theoretically, concurrent use may have additive effects.
  • AntioxidantsAntioxidants: In animal study, Coccinia indica displayed antioxidant properties, causing a reduction in plasma thiobarbituric acid reactive substances, hydroperoxides, vitamin E, and ceruloplasmin; significant increases in plasma vitamin C; and reduced glutathione (26; 27).
  • HypoglycemicsHypoglycemics: In human and studies, Coccinia indica has been shown to decrease blood sugar levels in humans (5; 4; 6; 7) and to have hypoglycemic effects in animals (9; 10; 14; 8; 16; 2; 1; 11; 13; 12; 15).
  • Vitamin CVitamin C: In animal research, an ethanolic extract of Coccinia indica leaves caused a significant increase in plasma vitamin C (26).
  • Vitamin EVitamin E: In animal research, an ethanolic extract of Coccinia indica leaves caused a significant reduction in plasma vitamin E (26).

    • Coccinia indica/Food Interactions:

  • Vitamin C-containing foodsVitamin C-containing foods: In animal research, an ethanolic extract of Coccinia indica leaves caused a significant increase in plasma vitamin C (26).
  • Vitamin E-containing foodsVitamin E-containing foods: In animal research, an ethanolic extract of Coccinia indica leaves caused a significant reduction in plasma vitamin E (26).

    • Coccinia indica/Lab Interactions:

  • Antioxidant statusAntioxidant status: In animal research, Coccinia indica has been shown to cause a reduction in plasma thiobarbituric acid reactive substances, hydroperoxides, vitamin E, and ceruloplasmin; significant increases in plasma vitamin C; and reduced glutathione (26; 27).
  • Blood glucoseBlood glucose: In human and studies, Coccinia indica has been shown to decrease blood sugar levels in humans (5; 4; 6; 7) and to have hypoglycemic effects in animals (9; 10; 14; 8; 16; 2; 1; 11; 13; 12; 15).
  • Collagen contentCollagen content: In animal research, the alpha:beta ratio of type I collagen and the type I:type III collagen ratio of pepsin-soluble collagen have been shown to be significantly decreased in streptozotocin diabetic rats (17).
  • Fatty acidsFatty acids: Oral administration of the ethanolic extract of Coccinia indica leaves to diabetic rats decreased the concentrations of the fatty acids palmitic, stearic, and oleic acid, whereas linolenic and arachidonic acid concentrations were elevated (15).
  • Glucose-6-phosphotase (G-6-p(ase))Glucose-6-phosphotase (G-6-p(ase)): Dried extract of Coccinia indica raised the activity of G-6-p(ase) in patients with diabetes (6).
  • Hemoglobin A1c (HbA1c)Hemoglobin A1c (HbA1c): In streptozotocin-treated diabetic rats, the leaf of Coccinia indica was shown to correct levels glycated hemoglobin (2; 1).
  • InsulinInsulin: Oral administration of the ethanolic extract of Coccinia indica leaves to diabetic rats was found to elevate insulin (15).
  • Lactate dehydrogenase (LDH)Lactate dehydrogenase (LDH): Dried extract of Coccinia indica raised the activity of LDH in patients with diabetes (6).
  • Lipoprotein lipase (LPL)Lipoprotein lipase (LPL): Dried extract of Coccinia indica reduced the enzyme activity of LPL in patients with diabetes (6)