Lathyrus

Lathyrus/Drug Interactions:

  • AnticoagulantsAnticoagulants: Both Lathyrus odoratus L. and Lathyrus silvestris L. contain lectins that nonspecifically agglutinated human erythrocytes in laboratory study, although D-mannose and D-glucose inhibited this hemagglutinating activity (14; 15).
  • Osteoporosis agentsOsteoporosis agents: Ingestion of Lathyrus sativus leaves or seeds may cause a disease called osteolathyrism, which includes bone pain and skeletal deformities, such as fusion failure in both vertebral and iliac epiphyses exhibited in two cases of osteolathyrism (8). In a controlled human study of urine samples from 54 volunteers that habitually consumed Lathyrus sativus, 25 showed no excretion of beta-diaminopropionic acid, while 29 showed an excretion of <0.7% the amount that was consumed (5). Peak urinary excretion occurred in the four-hour sample. Urinary oxalate was three times higher than the controls.

    • Lathyrus/Herb/Supplement Interactions:

  • Anticoagulants and antiplateletsAnticoagulants and antiplatelets: Both Lathyrus odoratus L. and Lathyrus silvestris L. contain lectins that nonspecifically agglutinated human erythrocytes in laboratory study, although D-mannose and D-glucose inhibited this hemagglutinating activity (14; 15).
  • CalciumCalcium: Ingestion of Lathyrus sativus leaves or seeds may cause a disease called osteolathyrism, which includes bone pain and skeletal deformities, such as fusion failure in both vertebral and iliac epiphyses exhibited in two cases of osteolathyrism (8). In a controlled human study of urine samples from 54 volunteers that habitually consumed Lathyrus sativus, 25 showed no excretion of beta-diaminopropionic acid, while 29 showed an excretion of <0.7% the amount that was consumed (5). Peak urinary excretion occurred in the four-hour sample. Urinary oxalate was three times higher than the controls.
  • Osteoporosis agentsOsteoporosis agents: Ingestion of Lathyrus sativus leaves or seeds may cause a disease called osteolathyrism, which includes bone pain and skeletal deformities, such as fusion failure in both vertebral and iliac epiphyses exhibited in two cases of osteolathyrism (8). In a controlled human study of urine samples from 54 volunteers that habitually consumed Lathyrus sativus, 25 showed no excretion of beta-diaminopropionic acid, while 29 showed an excretion of <0.7% the amount that was consumed (5). Peak urinary excretion occurred in the four-hour sample. Urinary oxalate was three times higher than the controls.
  • ZincZinc: According to one theory, adequate zinc intake may reduce the risk of toxicity due to chronically high doses of Lathyrus sativus seeds (9).

    • Lathyrus/Food Interactions:

  • CalciumCalcium: Ingestion of Lathyrus sativus leaves or seeds may cause a disease called osteolathyrism, which includes bone pain and skeletal deformities, such as fusion failure in both vertebral and iliac epiphyses exhibited in two cases of osteolathyrism (8). In a controlled human study of urine samples from 54 volunteers that habitually consumed Lathyrus sativus, 25 showed no excretion of beta-diaminopropionic acid, while 29 showed an excretion of <0.7% the amount that was consumed (5). Peak urinary excretion occurred in the four-hour sample. Urinary oxalate was three times higher than the controls.
  • Zinc-containing foodsZinc-containing foods: According to one theory, adequate zinc intake may reduce the risk of toxicity due to chronically high doses of Lathyrus sativus seeds (9).

    • Lathyrus/Lab Interactions:

  • CalciumCalcium: Ingestion of Lathyrus sativus leaves or seeds may cause a disease called osteolathyrism, which includes bone pain and skeletal deformities, such as fusion failure in both vertebral and iliac epiphyses exhibited in two cases of osteolathyrism (8). In a controlled human study of urine samples from 54 volunteers that habitually consumed Lathyrus sativus, 25 showed no excretion of beta-diaminopropionic acid, while 29 showed an excretion of <0.7% the amount that was consumed (5). Peak urinary excretion occurred in the four-hour sample. Urinary oxalate was three times higher than the controls.
  • Coagulation panelCoagulation panel: Both Lathyrus odoratus L. and Lathyrus silvestris L. contain lectins that nonspecifically agglutinated human erythrocytes in laboratory study, although D-mannose and D-glucose inhibited this hemagglutinating activity (14; 15).
  • UrinaryoxalateUrinaryoxalate: In a controlled human study of urine samples from 54 volunteers that habitually consumed Lathyrus sativus, 25 showed no excretion of beta-diaminopropionic acid, while 29 showed an excretion of <0.7% the amount that was consumed (5). Peak urinary excretion occurred in the four-hour sample. Urinary oxalate was three times higher than the controls.