Mandarin

Tangerine/Drug Interactions:

  • AntibioticsAntibiotics: Based on an in vitro study, Citrus reticulata may inhibit Helicobacter pylori (7).
  • AntidiabeticAntidiabetic: As a fruit of substantial sugar content, consumption of tangerines is likely to increase blood glucose levels.
  • Anti inflammatoriesAnti inflammatories: In a laboratory study, nobiletin, a polymethoxyflavonoid isolated from the citrus fruit Clivia nobilis, showed higher anti-inflammatory activity than indomethacin in a TPA-induced edema formation test in mouse ears (2). In theory, constituents found in citrus fruits, including tangerine, may have additive effects with other anti-inflammatory agents.
  • Antilipemic agentsAntilipemic agents: Based on a hamster model, tangerine juice may lower cholesterol and triglycerides (1).
  • Antineoplastic agentsAntineoplastic agents: Based on an in vitro study, tangerine peel or its extracts may have anticancer activity (4; 9; 6). In addition, tangerine and other Chinese medicinal herbs may decrease the toxic effects of chemotherapy, based on a case-control study of postoperative osteogenic sarcoma cases (11).
  • Cytochrome P450 metabolized agentsCytochrome P450 metabolized agents: Based on an in vitro study, tangeretin found in tangerine juice may stimulate CYP3A4 (12).

    • Tangerine/Herb/Supplement Interactions:

  • AntibacterialsAntibacterials: Based on an in vitro study, Citrus reticulata may inhibit Helicobacter pylori (7).
  • Anti inflammatoriesAnti inflammatories: In a laboratory study, nobiletin, a polymethoxyflavonoid isolated from the citrus fruit Clivia nobilis, showed higher anti-inflammatory activity than indomethacin in a TPA-induced edema formation test in mouse ears (2). In theory, constituents found in citrus fruits, including tangerine, may have additive effects with other herbs with anti-inflammatory effects.
  • AntilipemicsAntilipemics: Based on a hamster model, tangerine juice may lower cholesterol and triglycerides (1).
  • AntineoplasticsAntineoplastics: Based on an in vitro study, tangerine peel or its extracts may have anticancer activity (4; 9; 6). In addition, tangerine and other Chinese medicinal herbs may decrease the toxic effects of chemotherapy, based on a case-control study of postoperative osteogenic sarcoma cases (11).
  • AntioxidantsAntioxidants: Based on laboratory studies, tangerine may have antioxidant properties (1; 2; 3).
  • Cytochrome P450 metabolized herbs and supplementsCytochrome P450 metabolized herbs and supplements: Based on an in vitro study, tangeretin found in tangerine juice may stimulate CYP3A4 (12). However, the authors of this study note that tangerine juice is unlikely to have a clinical effect on CYP3A4 in humans.
  • HypoglycemicsHypoglycemics: As a fruit of substantial sugar content, consumption of tangerines is likely to increase blood glucose levels.

    • Tangerine/Food Interactions:

  • Insufficient available evidence.

    • Tangerine/Lab Interactions:

  • Blood glucoseBlood glucose: As a fruit of substantial sugar content, consumption of tangerines is likely to increase blood glucose levels.
  • Lipid panelLipid panel: Based on a hamster model, tangerine juice may lower cholesterol and triglycerides (1).
  • Serum levels of CYP450 metabolized agentsSerum levels of CYP450 metabolized agents: Based on an in vitro study, tangeretin found in tangerine juice may stimulate CYP3A4 (12). However, the authors of this study note that tangerine juice is unlikely to have a clinical effect on CYP3A4 in humans.