Maytenus krukovii

Chuchuhuasi/Drug Interactions:

  • AntibioticsAntibiotics: In lab study, an ethanolic extract of Maytenus macrocarpa demonstrated the broadest spectrum of action, inhibiting all of the tested strains with MICs ranging from 125-250mcg/mL (4). In other study, however, extracts of M. macrocarpa (5) and M. krukovii (6) bark lacked antibacterial effects.
  • AntifungalsAntifungals: In vitro, the hydroalcoholic extract of M. krukovii bark demonstrated weak antifungal activity against dermatophyte and phytopathogenic fungi (unspecified), although it inhibited the growth of phytopathogen Pythium ultimum (6).
  • Anti-inflammatoriesAnti-inflammatories: The anti-inflammatory effects of chuchuhuasi (most likely M. laevis) may be due to the presence of phenoldienones (tingenone, 22-hydroxytingenone), a catechin (4'-methyl-(-)-epigallocatechin), and proanthocyanidins (ouratea-proanthocyanidins A and B) (7).
  • AntineoplasticsAntineoplastics: In vitro, constituents of M. macrocarpa demonstrated marginal antitumor activity against four cell lines (unspecified) (8). In lab study, canophyllol from M. laevis demonstrated antitumor effects (9).
  • AntiprotozoalsAntiprotozoals: In vitro, sesquiterpenes isolated from M. macrocarpa may have antiparasitic activity against a multidrug-resistant Leishmania tropica line (10).

    • Chuchuhuasi/Herb/Supplement Interactions:

  • AntibacterialsAntibacterials: In lab study, an ethanolic extract of Maytenus macrocarpa demonstrated the broadest spectrum of action, inhibiting all of the tested strains with MICs ranging from 125 - 250mcg/mL (4). In other study, however, extracts of M. macrocarpa (5) and M. krukovii (6) bark lacked antibacterial effects.
  • AntifungalsAntifungals: In vitro, the hydroalcoholic extract of M. krukovii bark demonstrated weak antifungal activity against dermatophyte and phytopathogenic fungi (unspecified), although it inhibited the growth of phytopathogen Pythium ultimum (6).
  • Anti-inflammatoriesAnti-inflammatories: The anti-inflammatory effects of chuchuhuasi (most likely M. laevis) may be due to the presence of phenoldienones (tingenone, 22-hydroxytingenone), a catechin (4'-methyl-(-)-epigallocatechin), and proanthocyanidins (ouratea-proanthocyanidins A and B) (7).
  • AntineoplasticsAntineoplastics: In vitro, M. macrocarpa constituents demonstrated marginal antitumor activity against four cell lines (unspecified) (8). In lab study, canophyllol from M. laevis demonstrated antitumor effects (9).
  • AntioxidantsAntioxidants: In vitro, the hydroalcoholic extract of M. krukovii bark showed radical-scavenging activity (6). Based on secondary sources, M. guyanensis Klotzch. bark demonstrated antioxidant activity in vitro, based on tests involving reactions with 2,2,-diphenyl-1-picrylhydrazyl (DPPH).
  • AntiparasiticsAntiparasitics: In vitro, sesquiterpenes isolated from M. macrocarpa may have antiparasitic activity against a multidrug-resistant Leishmania tropica line (10). A constituent isolated from M. boaria seeds demonstrated antiparasitic effects against Spodoptera frugiperda with an LD50 value of 1.9ppm (11).

    • Chuchuhuasi/Food Interactions:

  • Insufficient available evidence.

    • Chuchuhuasi/Lab Interactions:

  • Insufficient available evidence.