Melaleuca leucadendron

Cajeput oil/Drug Interactions:

  • AnestheticsAnesthetics: Based on a study using cocaine, cajeput oil may intensify local anesthetic power when combined with other anesthetics (5).
  • AntibioticsAntibiotics: Based on an in vitro study, extracts from Melalleuce quinquenervia [sic] may have antibacterial activity when combined with selected antibiotics (6).
  • Antidiabetic agentsAntidiabetic agents: Based on an animal study, Melaleuca quinquenervia leaves may have a significant dose-dependent (35-70mg/kg) hypoglycemic effect (1).
  • AntihistaminesAntihistamines: Based on an in vitro study, chloroform and methanol extracts of Melaleuca quinquenervia fruits may have antihistamine effects (7).
  • AntihypertensivesAntihypertensives: Based on an in vitro study, Melaleuca quinquenervia leaves may either inhibit vascular contractile responses or significantly relax contractions, possibly by using nitric oxide as a mediator (2).
  • AntioxidantsAntioxidants: Based on an in vitro study, Melaleuca quinquenervia (Clav.) S. T. Blake may have antioxidant activity (1).
  • Antiulcer agentsAntiulcer agents: Based on an in vitro study, Melaleuca quinquenervia may inhibit the growth of Helicobacter pylori (4).
  • Antiviral agentsAntiviral agents: Based on a mouse HSV-1 infection assay, the fruit of Melaleuca quinquenervia may inhibit herpes simplex I (3).
  • Cytochrome P450 metabolized agentsCytochrome P450 metabolized agents: Based on an in vitro study, Melaleuca quinquenervia leaf may have a time-dependent increase of CYP2D6 inhibition (9).
  • Hypertensive drugsHypertensive drugs: Based on in vitro study, Melaleuca quinquenervia leaves may either inhibit vascular contractile responses or significantly relax contractions, possibly by using nitric oxide as a mediator (2).
  • Mosquito repellentsMosquito repellents: Based on a study using humans, cajeput may have mosquito repellent effects against Aedes aegypti (Linnaeus), Anopheles stephensi (Liston), and Culex quinquefasciatus (Say) (8).

    • Cajeput oil/Herb/Supplement Interactions:

  • AnestheticsAnesthetics: Based on a study using cocaine, cajeput oil may intensify local anesthetic power when combined with other anesthetics (5).
  • AntibacterialsAntibacterials: Based on an in vitro study, extracts from Melalleuce quinquenervia [sic] may have antibacterial activity when combined with selected antibiotics (6).
  • AntihistaminesAntihistamines: Based on an in vitro study, chloroform and methanol extracts of Melaleuca quinquenervia fruits may have antihistamine effects (7).
  • AntioxidantsAntioxidants: Based on an in vitro study, Melaleuca quinquenervia (Clav.) S. T. Blake may have antioxidant activity (1).
  • Antiulcer agentsAntiulcer agents: Based on an in vitro study, Melaleuca quinquenervia may inhibit the growth of Helicobacter pylori (4).
  • AntiviralsAntivirals: Based on a mouse HSV-1 infection assay, the fruit of Melaleuca quinquenervia may inhibit herpes simplex I (3).
  • Cytochrome P450 metabolized herbs and supplementsCytochrome P450 metabolized herbs and supplements: Based on an in vitro study, Melaleuca quinquenervia leaf may have a time-dependent increase of CYP2D6 inhibition (9).
  • HypertensivesHypertensives: Based on an in vitro study, Melaleuca quinquenervia leaves may either inhibit vascular contractile responses or significantly relax contractions, possibly by using nitric oxide as a mediator (2).
  • HypoglycemicsHypoglycemics: Based on an animal study, Melaleuca quinquenervia leaves may have a significant dose-dependent (35-70mg/kg) hypoglycemic effect (1).
  • HypotensivesHypotensives: Based on an in vitro study, Melaleuca quinquenervia leaves may either inhibit vascular contractile responses or significantly relax contractions, possibly by using nitric oxide as a mediator (2).
  • Mosquito repellentsMosquito repellents: Based on a study using humans, cajeput may have mosquito repellent effects against Aedes aegypti (Linnaeus), Anopheles stephensi (Liston), and Culex quinquefasciatus (Say) (8).

    • Cajeput oil/Food Interactions:

  • Insufficient available evidence.

    • Cajeput oil/Lab Interactions:

  • BUNBUN: Based on an animal study, Melaleuca quinquenervia leaves may reduce elevated blood urea nitrogen (BUN) levels in diabetics (1).
  • Helicobacter pylori testsHelicobacter pylori tests: Based on an in vitro study, Melaleuca quinquenervia may inhibit the growth of Helicobacter pylori (4).
  • Serum glucose levelsSerum glucose levels: Based on an animal study, Melaleuca quinquenervia leaves may have a significant dose-dependent (35-70mg/kg) hypoglycemic effect (1).
  • Serum levels of cytochrome P450 metabolized drugs or herbsSerum levels of cytochrome P450 metabolized drugs or herbs: Based on an in vitro study, Melaleuca quinquenervia leaf may have a time-dependent increase of CYP2D6 inhibition (9).