Mitragyna speciosa

Mitragyna speciosa/Drug Interactions:

  • AlcoholAlcohol: According to secondary sources, there have been reports of concomitant use of alcohol with Mitragyna speciosa causing oversedation or potential respiratory depression.
  • AnalgesicsAnalgesics: According to case report data, Mitragyna speciosa has been reported to have analgesic effects (7) and to have been used for chronic pain (9; 10; 11).
  • Antiobesity agentsAntiobesity agents: According to secondary sources, anorexia or weight loss may occur with use of Mitragyna speciosa.
  • BenzodiazepinesBenzodiazepines: According to secondary sources, there have been reports of concomitant use of benzodiazepines with Mitragyna speciosa causing oversedation or potential respiratory depression.
  • Caffeine-containing agentsCaffeine-containing agents: According to secondary sources, there have been reports of concomitant use of caffeine with Mitragyna speciosa causing overstimulation or elevated blood pressure.
  • CocaineCocaine: According to secondary sources, there have been reports of concomitant use of cocaine with Mitragyna speciosa causing overstimulation or elevated blood pressure.
  • Cytochrome P450 substratesCytochrome P450 substrates: In laboratory research, Mitragyna speciosa has shown the potential to interact with medications that are substrates for CYP3A4, CYP2D6, and CYP1A2 if used at the same time (26).
  • DiureticsDiuretics: According to anecdote, increase or decrease in urination may occur with use of Mitragyna speciosa.
  • Gastrointestinal agentsGastrointestinal agents: According to secondary sources, dry mouth, nausea, constipation, small black feces, and vomiting may occur with use of Mitragyna speciosa.
  • HepatotoxinsHepatotoxins: In a case report, intrahepatic cholestasis has been reported as an adverse effect of Mitragyna speciosa (25).
  • Monoamine oxidase inhibitors (MAOIs)Monoamine oxidase inhibitors (MAOIs): According to secondary sources, concomitant use of MAO inhibitors or certain other antidepressants with Mitragyna speciosa may potentially cause serious reactions.
  • Neurologic agentsNeurologic agents: According to secondary sources, there have been reports of concomitant use of neurologic agents with Mitragyna speciosa causing oversedation or potential respiratory depression. Mitragyna speciosa has reportedly been used for centuries for its psychoactive properties, opium-like effects, and ability to treat opioid addiction and opioid withdrawal (3; 4; 5; 6). According to case report data, Mitragyna speciosa has been reported to have analgesic and euphoric effects through its agonistic actions on opioid receptors (7).
  • OpioidsOpioids: According to secondary sources, there have been reports of concomitant use of opioids with Mitragyna speciosa causing oversedation or potential respiratory depression. Mitragyna speciosa has reportedly been used for centuries for its psychoactive properties, opium-like effects, and ability to treat opioid addiction and opioid withdrawal (3; 4; 5; 6). Reports starting in the mid-1800s give an account of Mitragyna speciosa being used as an opium substitute (13).
  • SedativesSedatives: According to secondary sources, there have been reports of concomitant use of sedatives with Mitragyna speciosa causing oversedation or potential respiratory depression.
  • StimulantsStimulants: According to secondary sources, there have been reports of concomitant use of amphetamine-like drugs with Mitragyna speciosa causing overstimulation or elevated blood pressure.
  • Thyroid hormonesThyroid hormones: In a reported case, the authors theorized that consumption of large doses of Mitragyna speciosa may have resulted in primary hypothyroidism caused by a reduction in the normal response of the thyroid gland to thyroid-stimulating hormone (24).
  • YohimbineYohimbine: According to secondary sources, there have been reports of concomitant use of yohimbine with Mitragyna speciosa causing overstimulation or elevated blood pressure.

    • Mitragyna speciosa/Herb/Supplement Interactions:

  • AnalgesicsAnalgesics: According to case report data, Mitragyna speciosa has been reported to have analgesic effects (7) and to have been used for chronic pain (9; 10; 11).
  • Antiobesity agentsAntiobesity agents: According to secondary sources, anorexia or weight loss may occur with use of Mitragyna speciosa.
  • Ayahuasca (Banisteriopsis caapi)Ayahuasca (Banisteriopsis caapi): According to secondary sources, concomitant use of MAO inhibitors, including Banisteriopsis caapi, with Mitragyna speciosa may potentially cause serious reactions.
  • Caffeine-containing agentsCaffeine-containing agents: According to secondary sources, there have been reports of concomitant use of caffeine with Mitragyna speciosa causing overstimulation or elevated blood pressure.
  • Coca (Erythroxylum coca)Coca (Erythroxylum coca): According to secondary sources, there have been reports of concomitant use of cocaine with Mitragyna speciosa causing overstimulation or elevated blood pressure.
  • Cytochrome P450 substratesCytochrome P450 substrates: In laboratory research, Mitragyna speciosa has shown the potential to interact with medications that are substrates for CYP3A4, CYP2D6, and CYP1A2 if used at the same time (26).
  • DiureticsDiuretics: According to anecdote, increase or decrease in urination may occur with use of Mitragyna speciosa.
  • Gastrointestinal agentsGastrointestinal agents: According to secondary sources, dry mouth, nausea, constipation, small black feces, and vomiting may occur with use of Mitragyna speciosa.
  • HepatotoxinsHepatotoxins: In a case report, intrahepatic cholestasis has been reported as an adverse effect of Mitragyna speciosa (25).
  • Monoamine oxidase inhibitors (MAOIs)Monoamine oxidase inhibitors (MAOIs): According to secondary sources, concomitant use of MAO inhibitors, including Syrian rue (Peganum harmala), ayahuasca (Banisteriopsis caapi), passionflower (Passiflora incarnata), or certain other antidepressants, with Mitragyna speciosa may potentially cause serious reactions.
  • Neurologic agentsNeurologic agents: According to secondary sources, there have been reports of concomitant use of neurologic agents with Mitragyna speciosa causing oversedation or potential respiratory depression. Mitragyna speciosa has reportedly been used for centuries for its psychoactive properties, opium-like effects, and ability to treat opioid addiction and opioid withdrawal (3; 4; 5; 6). According to case report data, Mitragyna speciosa has been reported to have analgesic and euphoric effects through its agonistic actions on opioid receptors (7).
  • Opium poppy (Papaver somniferum)Opium poppy (Papaver somniferum): According to secondary sources, there have been reports of concomitant use of opioids with Mitragyna speciosa causing oversedation or potential respiratory depression. Mitragyna speciosa has reportedly been used for centuries for its psychoactive properties, opium-like effects, and ability to treat opioid addiction and opioid withdrawal (3; 4; 5; 6). Reports starting in the mid-1800s give an account of Mitragyna speciosa being used as an opium substitute (13).
  • Passionflower (Passiflora incarnata)Passionflower (Passiflora incarnata): According to secondary sources, concomitant use of MAO inhibitors, including passionflower (Passiflora incarnata), with Mitragyna speciosa may potentially cause serious reactions.
  • SedativesSedatives: According to secondary sources, there have been reports of concomitant use of sedatives with Mitragyna speciosa causing oversedation or potential respiratory depression.
  • StimulantsStimulants: According to secondary sources, there have been reports of concomitant use of amphetamine-like agents with Mitragyna speciosa causing overstimulation or elevated blood pressure.
  • Syrian rue (Peganum harmala)Syrian rue (Peganum harmala): According to secondary sources, concomitant use of MAO inhibitors, including Syrian rue (Peganum harmala), with Mitragyna speciosa may potentially cause serious reactions.
  • Thyroid agentsThyroid agents: In a reported case, the authors theorized that consumption of large doses of Mitragyna speciosa may have resulted in primary hypothyroidism caused by a reduction in the normal response of the thyroid gland to thyroid-stimulating hormone (24).
  • Yohimbe (Pausinystalia yohimbe)Yohimbe (Pausinystalia yohimbe): According to secondary sources, there have been reports of concomitant use of yohimbine with Mitragyna speciosa causing overstimulation or elevated blood pressure.

    • Mitragyna speciosa/Food Interactions:

  • Caffeine-containing foodsCaffeine-containing foods: According to secondary sources, there have been reports of concomitant use of caffeine with Mitragyna speciosa causing overstimulation or elevated blood pressure.

    • Mitragyna speciosa/Lab Interactions:

  • Insufficient available evidence.