Morinda officinalis

Morinda officinalis/Drug Interactions:

  • AntidepressantsAntidepressants: In vitro (7; 8; 14; 9) and in animal research, (10; 13), constituents of Morinda officinalis had antidepressant effects.
  • AntidiabeticsAntidiabetics: In animal research, constituents of Morinda officinalis had hypoglycemic effects (5); theoretically, there is an increased risk for hypoglycemia.
  • Anti-inflammatoriesAnti-inflammatories: In animal research, constituents of Morinda officinalis had antinociceptive and anti-inflammatory actions (1; 2). In animal research, Morinda officinalis lowered serum levels of corticosterone (13).
  • AntineoplasticsAntineoplastics: In vitro, EquiguardT, a mixture of seven Chinese herbs, including Morinda officinalis, suppressed colony formation, inhibited cell proliferation, reduced expression of cell cycle regulatory proteins (including cyclin D1 and E2F), lowered androgen receptor and prostate-specific antigen levels, and decreased cyclooxygenase-2 in cancer cells (6).
  • Calcium saltsCalcium salts: In animal research, Morinda officinalis increased serum concentration of calcium (18).
  • Central nervous system (CNS) depressantsCentral nervous system (CNS) depressants: In animal research, constituents of Morinda officinalis increased the continuing swimming times of young mice (11; 12) and may theoretically interfere with the effects of CNS depressants.
  • CNS stimulantsCNS stimulants: In animal research, constituents of Morinda officinalis increased the continuing swimming times of young mice (11; 12); theoretically, concurrent use may have additive effects.
  • Drugs used for osteoporosisDrugs used for osteoporosis: In animal (16;15) and in vitro research, (17), constituents of Morinda officinalis had antiosteoporosis effects. In animal research, Morinda officinalis decreased serum osteocalcin (18).
  • Hormonal agentsHormonal agents: In animal research, Morinda officinalis increased serum concentration of estradiol (18) and testosterone (13).
  • ImmunosuppressantsImmunosuppressants: In animal research, Morinda officinalis increased white blood cell count and percentage (13).

    • Morinda officinalis/Herb/Supplement Interactions:

  • AntidepressantsAntidepressants: In vitro (7; 8; 14; 9) and in animal research, (10; 13), constituents of Morinda officinalis had antidepressant effects.
  • Anti-inflammatoriesAnti-inflammatories: In animal research, constituents of Morinda officinalis had antinociceptive and anti-inflammatory actions (1; 2). In animal research, Morinda officinalis lowered serum levels of corticosterone (13).
  • AntineoplasticsAntineoplastics: In vitro, EquiguardT, a mixture of seven Chinese herbs, including Morinda officinalis, suppressed colony formation, inhibited cell proliferation, reduced expression of cell cycle regulatory proteins (including cyclin D1 and E2F), lowered androgen receptor and prostate-specific antigen levels, and decreased cyclooxygenase-2 in cancer cells (6).
  • AntioxidantsAntioxidants: Constituents isolated from Morinda officinalis may have antioxidant properties, according to animal evidence (3; 4; 5). In animal research, Morinda officinalis increased levels of hepatic glutathione and the activity of hepatic superoxide dismutase (5).
  • CalciumCalcium: In animal research, Morinda officinalis increased serum concentration of calcium (18).
  • Hormonal herbs and supplementsHormonal herbs and supplements: In animal research, Morinda officinalis increased serum concentration of estradiol (18) and testosterone (13).
  • HypoglycemicsHypoglycemics: In animal research, constituents of Morinda officinalis had hypoglycemic effects (5); theoretically, there is an increased risk for hypoglycemia.
  • ImmunomodulatorsImmunomodulators: In animal research, Morinda officinalis increased white blood cell count and percentage (13).
  • Osteoporosis agentsOsteoporosis agents: In animal (16; 15) and in vitro research (17), constituents of Morinda officinalis had antiosteoporosis effects. In animal research, Morinda officinalis decreased serum osteocalcin (18).
  • PhosphorusPhosphorus: In animal research, Morinda officinalis increased serum concentration of phosphorus (18).
  • SedativesSedatives: In animal research, constituents of Morinda officinalis increased the continuing swimming times of young mice (11; 12) and may theoretically interfere with the effects of CNS depressants.
  • StimulantsStimulants: In animal research, constituents of Morinda officinalis increased the continuing swimming times of young mice (11; 12); theoretically, concurrent use may have additive effects.

    • Morinda officinalis/Food Interactions:

  • Insufficient available evidence.

    • Morinda officinalis/Lab Interactions:

  • CalciumCalcium: In animal research, Morinda officinalis increased serum concentration of calcium (18).
  • CorticosteroneCorticosterone: In animal research, Morinda officinalis lowered serum levels of corticosterone (13).
  • CytokinesCytokines: In animal research, Morinda officinalis decreased serum cytokine levels (16).
  • GlucoseGlucose: In animal research, Morinda officinalis reduced fasting blood glucose (5).
  • Hormone panelHormone panel: In animal research, Morinda officinalis increased serum concentration of estradiol (18) and testosterone (13).
  • OsteocalcinOsteocalcin: In animal research, Morinda officinalis decreased serum osteocalcin (18).
  • PhosphorusPhosphorus: In animal research, Morinda officinalis increased serum concentration of phosphorus (18).
  • White blood cellsWhite blood cells: In animal research, Morinda officinalis increased white blood cell count and percentage (13).