Morus nigra

Black mulberry/Drug Interactions:

  • Antidiabetic agentsAntidiabetic agents: Black mulberry may alter glucose levels.
  • Cytochrome P450 metabolized agentsCytochrome P450 metabolized agents: Based on in vitro study, black mulberry may inhibit cytochrome P450 (CYP450) 3A4 enzymes in a concentration-dependent manner (2).
  • MidazolamMidazolam: Commercial fruit juices, such as black mulberry juice, may have inhibitory effects on midazolam 1'-hydroxylase activity, a marker of CYP3A (2).
  • Sedative drugsSedative drugs: Mulberry has been traditionally used as a sedative.

    • Black mulberry/Herb/Supplement Interactions:

  • Cytochrome P450 metabolized herbs and supplementsCytochrome P450 metabolized herbs and supplements: Based on in vitro study, black mulberry may inhibit cytochrome P450 (CYP450) 3A4 enzymes in a concentration-dependent manner (2).
  • FigFig: A study has shown individuals allergic to black mulberry to have a possibly cross-allergy to fig (3).
  • HypoglycemicsHypoglycemics: Black mulberry may alter glucose levels.
  • MulberryMulberry: A study has shown individuals allergic to black mulberry to have a possibly cross-allergy to red, white and purple mulberry (3).
  • SedativesSedatives: Mulberry has been traditionally used as a sedative.

    • Black mulberry/Food Interactions:

  • FigFig A study has shown individuals allergic to black mulberry to have a possibly cross-allergy to fig (3).
  • Fruit/Fruit juices (white grapefruit, pomegranate, orange, black raspberry, plum, and wild grape)Fruit/Fruit juices (white grapefruit, pomegranate, orange, black raspberry, plum, and wild grape): Based on in vitro study, black mulberry, white grapefruit, pomegranate, orange, black raspberry, plum, and wild grape juice may inhibit cytochrome P450 (CYP450) 3A4 enzymes in a concentration-dependent manner (2).

    • Black mulberry/Lab Interactions:

  • Blood glucose monitoringBlood glucose monitoring: Black mulberry may alter glucose levels.
  • Liver testsLiver tests: Tests for hepatic enzyme activity and liver function may have erroneous results due to the concentration-dependent inhibition of CYP 3A4 enzymes by black mulberry (2).