Pimenta dioica

Allspice/Drug Interactions:

  • AnalgesicsAnalgesics: In rat study, allspice extracts demonstrated analgesic effects (3).
  • AntibioticsAntibiotics: In in vitro study, allspice demonstrated antibacterial effects (4; 5; 6; 7; 8; 9; 10). Conflicting evidence, however, exists (45; 46).
  • AntidiabeticsAntidiabetics: In in vitro study, allspice demonstrated antidiabetic effects (27; 28).
  • AntifungalsAntifungals: In in vitro study, allspice essential oil demonstrated antifungal effects (12; 13; 14).
  • AntihypertensivesAntihypertensives: In rat study, allspice extract produced a dose-dependent decrease in blood pressure (34; 33), although conflicting evidence exists regarding hypotensive effects (3).
  • Antilipemic agentsAntilipemic agents: In rat study, allspice extract demonstrated antihyperlipidemic effects in rats fed a high-fat diet (HFD) (32).
  • Antineoplastic agentsAntineoplastic agents: In in vitro and laboratory study, allspice reduced the growth of cancer cells (25; 17; 22).
  • Antiulcer agentsAntiulcer agents: In animal study, an aqueous suspension of Pimenta dioica demonstrated antiulcer and cytoprotective activity (2).
  • CNS depressantsCNS depressants: In rat study, Pimenta dioica extracts caused central nervous system (CNS) depression (3; 34).
  • Cytochrome P450metabolized agentsCytochrome P450-metabolized agents: Based on laboratory study, allspice enhanced CYP34A promoter activity (24).
  • EstrogensEstrogens: Based on laboratory study, Pimenta dioica extract demonstrated estrogenic effects (31).
  • Hematological agentsHematological agents: In mouse study, Pimenta dioica neutralized the hemorrhagic effect induced by Bothrops asper (Serpentes: Viperidae) venom (23).
  • ImmunosuppressantsImmunosuppressants: In laboratory study, constituents from Pimenta dioica induced proliferation of T-lymphocytes and macrophages (17).

    • Allspice/Herb/Supplement Interactions:

  • AnalgesicsAnalgesics: In rat study, allspice extracts demonstrated analgesic effects (3).
  • AntibacterialsAntibacterials: In in vitro study, allspice demonstrated antibacterial effects (4; 5; 6; 7; 8; 9; 10). Conflicting evidence, however, exists (45; 46).
  • AntifungalsAntifungals: In in vitro study, allspice essential oil demonstrated antifungal effects (12; 13; 14).
  • AntilipemicsAntilipemics: In rat study, allspice extract demonstrated antihyperlipidemic effects in rats fed a high fat diet (HFD) (32).
  • AntineoplasticsAntineoplastics: In in vitro and laboratory study, allspice reduced the growth of cancer cells (25; 17; 22).
  • AntioxidantsAntioxidants: Based on laboratory study, allspice constituents demonstrated antioxidant effects (11; 47; 18; 48; 17; 19; 49).
  • Antiulcer herbs and supplementsAntiulcer herbs and supplements: In animal study, an aqueous suspension of Pimenta dioica demonstrated antiulcer and cytoprotective activity (2).
  • Cytochrome P450-metabolized herbs and supplementsCytochrome P450-metabolized herbs and supplements: Based on laboratory study, allspice enhanced CYP34A promoter activity (24).
  • HematologicsHematologics: In mouse study, Pimenta dioica neutralized the hemorrhagic effect induced by Bothrops asper (Serpentes: Viperidae) venom (23).
  • HypoglycemicsHypoglycemics: In in vitro study, allspice demonstrated antidiabetic effects (27; 28).
  • HypotensivesHypotensives: In rat study, allspice extract produced a dose-dependent decrease in blood pressure (34; 33), although conflicting evidence for hypotensive effects exists (3).
  • ImmunosuppressantsImmunosuppressants: In laboratory study, constituents from Pimenta dioica induced proliferation of T-lymphocytes and macrophages (17).
  • PhytoestrogensPhytoestrogens: Based on laboratory study, Pimenta dioica extract demonstrated estrogenic effects (31).
  • SedativesSedatives: In rat study, Pimenta dioica extracts caused central nervous system (CNS) depression (3; 34).

    • Allspice/Food Interactions:

  • Low-sodium foodsLow-sodium foods: In human study, reduced sodium beef broth was more palatable when allspice was used (30). The authors concluded that allspice may be a satisfying substitute for sodium in foods.
  • Rapeseed oilRapeseed oil: In laboratory study, a rapeseed oil sample treated with allspice extract demonstrated the greatest resistance against lipid oxidation (49).

    • Allspice/Lab Interactions:

  • Blood pressureBlood pressure: In mouse study, allspice extract induced dose-dependent hypotensive effects (34).
  • Blood glucoseBlood glucose: In in vitro study, allspice demonstrated antidiabetic effects (27; 28).
  • Levels of drugs metabolized by CYP450Levels of drugs metabolized by CYP450: Based on laboratory study, allspice enhanced CYP34A promoter activity (24).
  • Lipid profileLipid profile: In rat study, allspice extract demonstrated antihyperlipidemic effects in rats fed a high-fat diet (HFD) (32).
  • WBC (white blood cell) countWBC (white blood cell) count: In laboratory study, constituents from Pimenta dioica induced proliferation of T-lymphocytes and macrophages (17).