Purple nutsedge

Purple nutsedge/Drug Interactions:

  • AntibioticsAntibiotics: Based on in vitro studies, induction of apoptosis may provide purple nutsedge with antibacterial properties (1; 2).
  • Anticoagulants and antiplateletsAnticoagulants and antiplatelets: In animal studies, a combination of Cyperus rotundus with other herbs (peony root, Cnidium rhizome, safflower, Saussurea root (JP XIV)) inhibited the aggregation of platelets without affecting the prothrombin time (3; 4; 5).
  • Antidiabetic agentsAntidiabetic agents: In lab and animal studies, Cyperus rotundus was found to inhibit protein glycation and reduce blood glucose (9; 6).
  • AntidiarrhealsAntidiarrheals: In animal studies, the methanol extract of Cyperus rotundus significantly reduced castor oil-induced diarrhea (10).
  • Anti-inflammatory agentsAnti-inflammatory agents: In in vitro studies, an overproduction of nitric oxide and superoxide in the murine macrophage cell line RAW264.7 was inhibited by the methanolic extract of Cyperus rotundus (12).
  • Antimalarial agentsAntimalarial agents: In in vitro research, constituents of Cyperus rotundus showed antimalarial activity (14).
  • Antineoplastic agentsAntineoplastic agents: Based on in vitro studies, Cyperus rotundus may induce programmed cell death (1; 2; 13).
  • Cholinesterase inhibitorsCholinesterase inhibitors: In animal and plant studies, purple nutsedge inhibited acetylcholinesterase (AChE) (16).
  • Drugs that affect GABADrugs that affect GABA: Cyperus rotundus is anecdotally said to improve epilepsy. In animal research, one constituent of purple nutsedge, isocurcumenol, interacted in vitro with the benzodiazepine receptor (17).

    • Purple nutsedge/Herb/Supplement Interactions:

  • Anticoagulants and antiplateletsAnticoagulants and antiplatelets: In animal studies, a combination of Cyperus rotundus with other herbs (peony root, Cnidium rhizome, safflower, Saussurea root (JP XIV)) inhibited the aggregation of platelets without affecting the prothrombin time (3; 4; 5).
  • AntidiarrhealsAntidiarrheals: In animal studies, the methanol extract of Cyperus rotundus significantly reduced castor oil-induced diarrhea (10).
  • Anti-inflammatory herbsAnti-inflammatory herbs: In in vitro studies, an overproduction of nitric oxide and superoxide in the murine macrophage cell line RAW264.7 was inhibited by the methanolic extract of Cyperus rotundus (12).
  • Antimalarial herbs and supplementsAntimalarial herbs and supplements: In in vitro research, constituents of Cyperus rotundus showed antimalarial activity (14).
  • AntineoplasticsAntineoplastics: Based on in vitro studies, Cyperus rotundus may induce programmed cell death (1; 2; 13).
  • AntioxidantsAntioxidants: Based on in vitro research, Cyperusrotundus may have antioxidant effects (9; 1; 2; 6; 7).
  • Cholinergic herbsCholinergic herbs: In animal and plant studies, purple nutsedge inhibits acetylcholinesterase (AChE) (16).
  • HypoglycemicsHypoglycemics: In lab and animal studies, Cyperus rotundus was found to inhibit protein glycation and reduce blood glucose (9; 6).

    • Purple nutsedge/Food Interactions:

  • Insufficient evidence.

    • Purple nutsedge/Lab Interactions:

  • Blood glucoseBlood glucose: Based on animal studies, Cyperus rotundus may lower blood sugar levels (9; 6).
  • Coagulation panelCoagulation panel: In animal studies, a combination of Cyperus rotundus with other herbs (peony root, Cnidium rhizome, safflower, Saussurea root (JP XIV)) inhibited the aggregation of platelets without affecting the prothrombin time (3; 4; 5).