Sangre de grado

Sangre de grado/Drug Interactions:

  • AntibioticsAntibiotics: In vitro, various constituents from sangre de grado demonstrated antibacterial activity (16). Additional details are lacking.
  • AntidiarrhealsAntidiarrheals: In vitro, SP-300 blocked forskolin-stimulated Cl- secretion in human colonic T84 cells. Similar effects were observed with the SP-303 formulation. Administration of cholera toxin to adult mice increased fluid accumulation in the small intestine, which was reduced following treatment with 100mg/kg when administered alongside the cholera treatment. SP-303 significantly affected basal current and forskolin-stimulated Cl- current (19).
  • Anti-inflammatory agentsAnti-inflammatory agents: Taspine from the sap of Croton lechleri L. may reduce inflammation, as measured through the carrageenan-induced pedal edema method, the cotton pellet-induced granuloma method, and the adjuvant polyarthritis model (20). Additional details are lacking.
  • AntineoplasticsAntineoplastics: In human cancer cells (AGS (stomach), HT29, and T84 (colon)), treatment with sangre de grado decreased cell viability and cell proliferation (3). Furthermore, in suspended cells, treatment with sangre de grado decreased cell adherence and induced apoptosis, as evidenced by nucleus condensation and DNA fragmentation. Taspine from Croton lechleri induced conformational activation of the proapoptotic proteins Bak and Bax, mitochondrial cytochrome c release, and mitochondrial membrane permeabilization in HCT116 cells (4).
  • AntiviralsAntivirals: According to secondary sources, a constituent of sangre de grado, taspine, may exert antiviral activity against herpes virus, influenza virus, parainfluenza, and hepatitis.
  • Cardiovascular agentsCardiovascular agents: In vitro, sangre de grado induced endothelium-independent, concentration-dependent vasoconstriction in rat caudal arteries (21). Sangre de grado also produced a concentration-dependent vasoconstriction in arterial tissues that were preconstricted through administration of phenylephrine.
  • Dermatologic agentsDermatologic agents: In vitro, sangre de grado significantly decreased the basal release of substance P in a model of cutaneous neurogenic inflammation (22). Incubation with sangre de grado also inhibited capsaicin-induced substance P release.
  • Gastrointestinal agentsGastrointestinal agents: In rats, acetic acid-induced gastric ulcers were healed following administration of sangre de grado, as evidenced by a reduction in myeloperoxidase activity, ulcer size, and bacterial content of the ulcer (23). Sangre de grado also reduced ulcer-induced increases in proinflammatory genes, tumor necrosis factor-alpha, inducible nitric oxide synthase (iNOS), interleukin (IL)-1beta, IL-6, and cyclooxygenase-2.
  • ImmunosuppressantsImmunosuppressants: In vitro, sangre de grado inhibited classical and alternative complementary pathways and inhibited the proliferation of activated T cells (24).
  • Wound-healing agentsWound-healing agents: In mice, taspine from sangre de grado was identified as the main scar-forming agent, with an ED50 of 0.375mg/kg (17). Taspine was found to increase the migration of human foreskin fibroblasts. In a rat surgical incision model, taspine purified from Croton (species unspecified) tree sap increased mononuclear cellular filtration after five days of treatment, but not after 12 days (25). In vitro, taspine stimulated fibroblast chemotaxis, with no effect on macrophage chemotaxis, neutrophil activation, fibroblast proliferation, or matrix assembly.

    • Sangre de grado/Herb/Supplement Interactions:

  • AntibacterialsAntibacterials: In vitro, various constituents from sangre de grado demonstrated antibacterial activity (16). Additional details are lacking.
  • AntidiarrhealsAntidiarrheals: In vitro, SP-300 blocked forskolin-stimulated Cl- secretion in human colonic T84 cells. Similar effects were observed with the SP-303 formulation. Administration of cholera toxin to adult mice increased fluid accumulation in the small intestine, which was reduced following treatment with 100mg/kg when administered alongside the cholera treatment (19).
  • Anti-inflammatory agentsAnti-inflammatory agents: Taspine from the sap of Croton lechleri L. may reduce inflammation, as measured through the carrageenan-induced pedal edema method, the cotton pellet-induced granuloma method, and the adjuvant polyarthritis model (20). Additional details are lacking.
  • AntineoplasticsAntineoplastics: In human cancer cells (AGS (stomach), HT29, and T84 (colon)), treatment with sangre de grado decreased cell viability and cell proliferation (3). Furthermore, in suspended cells, treatment with sangre de grado decreased cell adherence and induced apoptosis, as evidenced by nucleus condensation and DNA fragmentation. Taspine from Croton lechleri induced conformational activation of the proapoptotic proteins Bak and Bax, mitochondrial cytochrome c release, and mitochondrial membrane permeabilization in HCT116 cells (4).
  • AntioxidantsAntioxidants: In vitro, flavan-3-ols derivatives from sangre de grado exhibited the highest antioxidant activity (26). Sangre de grado from Croton lechleri Muell.-Arg. demonstrated total reactive antioxidant potential (TRAP) (27). Sangre de grado showed antioxidant activity against apomorphine-induced oxidative stress in Saccharomyces cerevisiae (18). It was also observed to protect maize plantlet cells from the toxic effects of apomorphine.
  • AntiviralsAntivirals: According to secondary sources, a constituent of sangre de grado, taspine, may exert antiviral activity against herpes virus, influenza virus, parainfluenza, and hepatitis.
  • Cardiovascular agentsCardiovascular agents: In vitro, sangre de grado induced endothelium-independent, concentration-dependent vasoconstriction in rat caudal arteries (21). Sangre de grado also produced a concentration-dependent vasoconstriction in arterial tissues that were preconstricted through administration of phenylephrine.
  • Dermatologic agentsDermatologic agents: In vitro, sangre de grado significantly decreased basal release of substance P in a model of cutaneous neurogenic inflammation (22). Incubation with sangre de grado also inhibited capsaicin-induced substance P release.
  • Gastrointestinal agentsGastrointestinal agents: In rats, acetic acid-induced gastric ulcers were healed following administration of sangre de grado, as evidenced by a reduction in myeloperoxidase activity, ulcer size, and bacterial content of the ulcer (23). Sangre de grado also reduced ulcer-induced increases in proinflammatory genes, tumor necrosis factor-alpha, inducible nitric oxide synthase (iNOS), interleukin (IL)-1beta, IL-6, and cyclooxygenase-2.
  • ImmunomodulatorsImmunomodulators: In vitro, sangre de grado inhibited classical and alternative complementary pathways and inhibited the proliferation of activated T cells (24).
  • Wound-healing herbs and supplementsWound-healing herbs and supplements: In mice, taspine from sangre de grado was identified as the main scar-forming agent, with an ED50 of 0.375mg/kg (17). Taspine was found to increase the migration of human foreskin fibroblasts. In a rat surgical incision model, taspine purified from Croton (species unspecified) tree sap increased mononuclear cellular filtration after five days of treatment, but not after 12 days (25). In vitro, taspine stimulated fibroblast chemotaxis with no effect on macrophage chemotaxis, neutrophil activation, fibroblast proliferation, or matrix assembly.

    • Sangre de grado/Food Interactions:

  • Insufficient available evidence.

    • Sangre de grado/Lab Interactions:

  • Insufficient available evidence.