Scullcap

Scullcap/Drug Interactions:

  • Antidepressants, monoamine oxidase inhibitors (MAOIs)Antidepressants, monoamine oxidase inhibitors (MAOIs): In in vitro research, Scutellaria lateriflora inhibited the 5-HT(7) receptor, an action that seems to have antidepressant effects (2).
  • Antidepressants, selective serotonin reuptake inhibitors (SSRIs)Antidepressants, selective serotonin reuptake inhibitors (SSRIs): In in vitro research, Scutellaria lateriflora inhibited the 5-HT(7) receptor, an action that seems to have antidepressant effects (2).
  • AntispasmodicsAntispasmodics: According to secondary sources, scullcap may have antispasmodic effects.
  • HepatotoxinsHepatotoxins: According to human research, scullcap may cause liver damage (5).
  • AnxiolyticsAnxiolytics: In human research, Scutellaria lateriflora had anxiolytic effects (1). According to animal research, scullcap contains a flavonoid, baicalin, which is reported to bind to the benzodiazepine site of the GABA-A receptor (4).
  • BenzodiazepinesBenzodiazepines: In human research, Scutellaria lateriflora had anxiolytic effects (1). According to animal research, scullcap contains a flavonoid, baicalin, which is reported to bind to the benzodiazepine site of the GABA-A receptor (4).
  • Neurologic agentsNeurologic agents: According to secondary sources, high doses of scullcap may cause giddiness, stupor, confusion, and other symptoms suggestive of epilepsy.
  • SedativesSedatives: According to animal research, scullcap may have sedative effects (4).

    • Scullcap/Herb/Supplement Interactions:

  • Antidepressants, monoamine oxidase inhibitors (MAOIs)Antidepressants, monoamine oxidase inhibitors (MAOIs): In in vitro research, Scutellaria lateriflora inhibited the 5-HT(7) receptor, an action that seems to have antidepressant effects (2).
  • Antidepressants, selective serotonin reuptake inhibitors (SSRIs)Antidepressants, selective serotonin reuptake inhibitors (SSRIs): In in vitro research, Scutellaria lateriflora inhibited the 5-HT(7) receptor, an action that seems to have antidepressant effects (2).
  • AntispasmodicsAntispasmodics: According to secondary sources, scullcap may have antispasmodic effects.
  • AnxiolyticsAnxiolytics: In human research, Scutellaria lateriflora had anxiolytic effects (1). According to animal research, scullcap contains a flavonoid, baicalin, which is reported to bind to the benzodiazepine site of the GABA-A receptor (4).
  • HepatotoxinsHepatotoxins: According to human research, scullcap may cause liver damage (5).
  • Neurologic agentsNeurologic agents: According to secondary sources, high doses of scullcap may cause giddiness, stupor, confusion, and other symptoms suggestive of epilepsy.
  • SedativesSedatives: According to animal research, scullcap may have sedative effects (4).

    • Scullcap/Food Interactions:

  • Insufficient available evidence.

    • Scullcap/Lab Interactions:

  • Liver panelLiver panel: According to human research, scullcap may cause liver damage (5).