Sinupret

Sorrel/Drug Interactions:

  • GeneralGeneral: In theory, precipitation of some drugs may occur when taken concomitantly with sorrel. Therefore, separate administration is recommended.
  • Alkaloid agentsAlkaloid agents: In theory, herbs with high tannin content, such as sorrel, should not be used in combination with alkaloid agents (e.g. vinblastine) due to the possibility of precipitate formation.
  • AntibioticsAntibiotics: Positive interaction: Concurrent use of doxycycline with Quanterra? Sinus Defense or Sinupret? has been shown to synergistically improve outcomes in patients with acute bacterial sinusitis (4). Additional supporting evidence in this area is limited.
  • Antineoplastic agentsAntineoplastic agents: Sorrel is popularly taken in Essiac? as a cancer therapy. Although there is a lack of available human evidence for this indication, laboratory studies suggest sorrel may have antiproliferative and cytotoxic effects; therefore sorrel and sorrel combination products (e.g. Essiac?, Flor-Essence?) may theoretically interact with other cancer therapies (7; 8).
  • AntiviralsAntivirals: In an in vitro study, sorrel did not demonstrate activity against herpes simplex virus-1, herpes simplex virus-2, or HIV (5).
  • Disulfiram (Antabuse?)Disulfiram (Antabuse?): Many tinctures contain high levels of alcohol and may cause nausea or vomiting when taken with disulfiram (Antabuse?).
  • DiureticsDiuretics: Polyuria has been reported anecdotally with the use of sorrel and may therefore add to the effects of diuretics.
  • Gastrointestinal agents, miscellaneousGastrointestinal agents, miscellaneous: Theoretically, sorrel may interact with gastrointestinal agents.
  • Hepatotoxic agentsHepatotoxic agents: In large amounts, ingestion of sorrel may lead to liver damage (9) and should be avoided with hepatotoxic agents.
  • Metronidazole(Flagyl?)Metronidazole(Flagyl?): Many tinctures contain high levels of alcohol and may cause nausea or vomiting when taken with metronidazole (Flagyl?).
  • Nephrotoxic agentsNephrotoxic agents: Because the consumption of sorrel in large amounts may lead to kidney stones or kidney damage, it should be avoided with agents that are nephrotoxic (9; 6).

    • Sorrel/Herb/Supplement Interactions:

  • GeneralGeneral: In theory, precipitation of some herbs or supplements may occur when taken concomitantly with sorrel. Therefore, separate administration is recommended.
  • Alkaloid agentsAlkaloid agents: In theory, herbs with high tannin content, such as sorrel, should not be used in combination with alkaloid agents (e.g. atropine, belladonna, galantamine, or scopolamine) due to the possibility of precipitate formation.
  • AntibacterialsAntibacterials: Positive interaction: Concurrent use of doxycycline with Quanterra? Sinus Defense or Sinupret? has been shown to synergistically improve outcomes in patients with acute bacterial sinusitis (4). Additional supporting evidence in this area is limited.
  • AntineoplasticsAntineoplastics: Sorrel is popularly taken in Essiac? as a cancer therapy. Although there is a lack of available human evidence for this indication, laboratory studies suggest sorrel has antiproliferative and cytotoxic effects; therefore sorrel and sorrel combination products (e.g. Essiac?, Flor-Essence?) may theoretically interact with other cancer therapies (7; 8).
  • AntiviralsAntivirals: In an in vitro study, sorrel did not demonstrate activity against herpes simplex virus-1, herpes simplex virus-2, or HIV (5).
  • CalciumCalcium: Sorrel may impair calcium absorption due to its high oxalate content. Therefore, separate administration is recommended.
  • DiureticsDiuretics: Polyuria has been reported anecdotally with the use of sorrel and may therefore add to the effects of diuretics.
  • Gastrointestinal herbs and supplementsGastrointestinal herbs and supplements: Theoretically, sorrel may interact with gastrointestinal herbs and supplements.
  • Hepatotoxic herbsHepatotoxic herbs: In large amounts, ingestion of sorrel may lead to liver damage (9). Therefore, sorrel should be avoided with agents that are hepatotoxic.
  • IronIron: Sorrel may impair iron absorption due to its high oxalate content. Therefore, separate administration is recommended.
  • Nephrotoxic agentsNephrotoxic agents: Because the consumption of sorrel in large amounts may lead to kidney stones or kidney damage, it should be avoided with agents that are nephrotoxic (9; 6).
  • RhubarbRhubarb: Rhubarb contains oxalate, which may add to the toxic effects of oxalate in sorrel if used concomitantly.
  • ShamrockShamrock: Shamrock contains oxalate, which may add to the toxic effects of oxalate in sorrel if used concomitantly.
  • ZincZinc: Sorrel may impair zinc absorption due to its high oxalate content. Therefore, separate administration is recommended.

    • Sorrel/Food Interactions:

  • Minerals (calcium, iron, zinc)Minerals (calcium, iron, zinc): Sorrel may impair absorption of calcium, iron, and zinc due to its oxalate content. Therefore, separate administration is recommended.

    • Sorrel/Lab Interactions:

  • Mineral absorptionMineral absorption: Sorrel may impair calcium, iron, and zinc absorption due to its high oxalate content. Therefore, separate administration is recommended.