Tabebuia

Pau d'arco/Drug Interactions:

  • AntacidsAntacids: An ethanolic extract of bark from Tabebuia avellanedae has been shown to significantly reduce basal gastric acid secretion and total acidity in rats (8). The effects of pau d'arco with antacids are not well understood.
  • Antiangiogenic drugsAntiangiogenic drugs: Based on in vitro experimentation, beta-lapachone may have antiangiogenic properties (9). The effects of pau d'arco with antiangiogenic agents are not well understood.
  • Anticoagulants and antiplateletsAnticoagulants and antiplatelets: Extracts of Tabebuia impetiginosa (taheebo) inner bark have been shown to inhibit platelet aggregation induced by collagen and arachidonic acid (AA) in a dose-dependent manner in vitro (6). However, in animal study, prothrombin time has been reported as unaltered six hours after oral administration of lapachol (18). Caution is warranted, as pau d'arco may theoretically increase the risk of bleeding.
  • Anti inflammatory agentsAnti inflammatory agents: A water extract of Tabebuia avellanedae (taheebo) has been shown to exhibit anti-inflammatory activity in a mouse ear edema model, via strong inhibition of PGE(2) production (4). An ethanolic extract of bark from Tabebuia avellanedae has been shown to significantly reduce ibuprofen-induced gastric damage in rats (8). A water extract of Tabebuia avellanedae (taheebo) has been shown to exhibit anti-inflammatory activity in a mouse ear edema model, via strong inhibition of PGE(2) production (4).
  • Antineoplastic agentsAntineoplastic agents: Preparations and constituents of Tabebuia spp. have demonstrated a variety of anticancer activities in vitro and in vivo, including antiangiogenic, antimetastatic, anti-invasive, apoptotic, antiproliferative, and antimyelosuppressive properties (10; 11; 6; 12; 9; 13; 14; 15). The effects of pau d'arco with antineoplastic agents are not well understood.
  • EthanolEthanol: An ethanolic extract of bark from Tabebuia avellanedae has been shown to significantly reduce ethanol-induced gastric damage in rats (8).
  • ImmunosuppressantsImmunosuppressants: Aqueous extracts of Tabebuia avellanedae (Tabebuia) inner bark have demonstrated inhibitory effects on lymphocyte proliferation in vitro (16). Theoretically, pau d'arco may cause additive immunosuppression.

    • Pau d'arco /Herb/Supplement Interactions:

  • AntacidsAntacids: An ethanolic extract of bark from Tabebuia avellanedae has been shown to significantly reduce basal gastric acid secretion and total acidity in rats (8). The effects of pau d'arco with antacids are not well understood.
  • Antiangiogenic herbsAntiangiogenic herbs: Based on in vitro experimentation, beta-lapachone may have antiangiogenic properties (9). The effects of pau d'arco with antiangiogenic agents are not well understood.
  • Anticoagulants and antiplateletsAnticoagulants and antiplatelets: Extracts of Tabebuia impetiginosa (taheebo) inner bark have been shown to inhibit platelet aggregation induced by collagen and arachidonic acid (AA) in a dose-dependent manner in vitro (6). However, in animal study, prothrombin time has been reported as unaltered six hours after oral administration of lapachol (18). Caution is warranted as Pau d'arco may theoretically increase the risk of bleeding.
  • Anti inflammatory agentsAnti inflammatory agents: A water extract of Tabebuia avellanedae (taheebo) has been shown to exhibit anti-inflammatory activity in a mouse ear edema model, via strong inhibition of PGE(2) production (4). An ethanolic extract of bark from Tabebuia avellanedae has been shown to significantly reduce ibuprofen-induced gastric damage in rats (8). A water extract of Tabebuia avellanedae (taheebo) has been shown to exhibit anti-inflammatory activity in a mouse ear edema model, via strong inhibition of PGE(2) production (4).
  • AntineoplasticsAntineoplastics: Preparations and constituents of Tabebuia spp. have demonstrated a variety of anticancer activities in vitro and in vivo, including antimetastatic, anti-invasive, apoptotic, antiproliferative, and antimyelosuppressive properties (10; 11; 6; 12; 9; 13; 14; 15). The effects of pau d'arco with antineoplastic agents are not well understood.
  • ImmunosuppressantsImmunosuppressants: Aqueous extracts of Tabebuia avellanedae (Tabebuia) inner bark have demonstrated inhibitory effects on lymphocyte proliferation in vitro (16). Theoretically, pau d'arco may cause additive immunosuppression.
  • Vitamin KVitamin K: Secondary sources report that the effects of pau d'arco on blood clotting can be reversed by vitamin K.

    • Pau D'Arco/Food Interactions:

  • Vitamin KVitamin K: Secondary sources report that the effects of pau d'arco on blood clotting can be reversed by vitamin K.

    • Pau D'Arco/Lab Interactions:

  • Coagulation panelCoagulation panel: Extracts of Tabebuia impetiginosa (taheebo) inner bark have been shown to inhibit platelet aggregation induced by collagen and arachidonic acid (AA) in a dose-dependent manner in vitro (6). However, in animal study, prothrombin time has been reported as unaltered six hours after oral administration of lapachol (18).
  • White blood cellsWhite blood cells Aqueous extracts of Tabebuia avellanedae (Tabebuia) inner bark have demonstrated inhibitory effects on lymphocyte proliferation in vitro (16). Treatment with both Tabebuia avellanedae and beta-lapachone in Ehrlich ascites tumor-bearing mice has been shown to result in a reversal of increases in spleen CFU-GM and serum colony-stimulating activity (CSA) that are concomitant with myelosuppression (13).