Tormentil

Tormentil/Drug Interactions:

  • Agglutinating agentsAgglutinating agents: Tannins isolated from tormentil have been shown to have agglutinating effects (19).
  • AntibioticsAntibiotics: In a clinical trial of patients with active pulmonary tuberculosis, an herbal extract containing tormentil (Potentilla erecta) showed a higher rate of conversion to negative sputum smears when used together with standard treatment, compared with standard treatment alone (17). Tannins isolated from tormentil have been shown to have bacteriostatic effects (19). In laboratory research, polyphenols extracted from tormentil and other plants of the Geraniaceae and Rosaceae families collectively have shown antibacterial activity against Gram-negative and Gram-positive species of the Azobacter, Bacillus, and Pseudomonas genera, including Bacillus cereus, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus strains (20).
  • AnticoagulantsAnticoagulants: According to secondary sources, tormentil may affect blood coagulation. The exact mechanism of action is not well known, based on the available literature.
  • AntidiabeticsAntidiabetics: According to secondary sources, tormentil may lower blood glucose. The exact mechanism of action is not well known, based on the available literature.
  • Antielastase agentsAntielastase agents: Procyanidin pentamers and hexamers extracted from tormentil exhibited greater antielastase activity than polymers of other sizes in laboratory assays (21).
  • Anti-inflammatoriesAnti-inflammatories: In patients with erosive ulcerative lichen planus of the buccal mucosa, supplementation of standard treatment with gargling with tincture of Potentilla tormentilla together with local application of codfish oil led to more rapid improvement than standard treatment alone (16). In vitro, a water extract of Potentilla erecta showed potent cyclooxygenase inhibition, as well as inhibition of prostaglandin biosynthesis and platelet activating factor-induced exocytosis (3).
  • AntiviralsAntivirals: In a randomized controlled trial, tormentil root extract therapy was associated with shortened rotaviral diarrhea duration and reduced need for rehydration solution in children (11).
  • Cytotoxic agentsCytotoxic agents: Potentilla erecta extracts have been shown to inhibit the growth of cultured human Raji cells at concentrations of 10 and 50mcg/mL (22).
  • Gastrointestinal agentsGastrointestinal agents: In a trial in patients with ulcerative colitis, tormentil extract treatment was associated with improvements in the clinical activity index (CAI) (10). In this same study, mild abdominal pain was reported as an adverse effect (10). In a randomized controlled trial, tormentil root extract therapy was associated with shortened rotaviral diarrhea duration and reduced need for rehydration solution in children (11).
  • Growth-promoting agentsGrowth-promoting agents: Supplementation of cell cultures with tormentil rhizome extract, together with an antibiotic (such as cefoperazone, cefuroxime, or doxycycline) and hydrocortisone, has been shown to enhance cell survival (23).
  • HepatotoxinsHepatotoxins: In a clinical trial of patients with active pulmonary tuberculosis (TB), an herbal extract containing tormentil (Potentilla erecta) appeared to minimize or reverse liver damage caused by standard anti-TB therapy (17).
  • HydrocortisoneHydrocortisone: Supplementation of cell cultures with tormentil rhizome extract, together with an antibiotic and hydrocortisone, has been shown to enhance cell survival (23).
  • Pulmonary agentsPulmonary agents: In a clinical trial of patients with active pulmonary tuberculosis, an herbal extract containing tormentil (Potentilla erecta), showed a higher rate of healing of pulmonary infiltrations and cavities when used together with standard treatment, compared with standard treatment alone (17).

    • Tormentil/Herb/Supplement Interactions:

  • Agglutinating agentsAgglutinating agents: Tannins isolated from tormentil have been shown to have agglutinating effects (19).
  • AntibacterialsAntibacterials: In a clinical trial of patients with active pulmonary tuberculosis, an herbal extract containing tormentil (Potentilla erecta) showed a higher rate of conversion to negative sputum smears when used together with standard treatment, compared with standard treatment alone (17). Tannins isolated from tormentil have been shown to have bacteriostatic effects (19). In laboratory research, polyphenols extracted from tormentil and other plants of the Geraniaceae and Rosaceae families collectively have shown antibacterial activity against Gram-negative and Gram-positive species of the Azobacter, Bacillus, and Pseudomonas genera, including Bacillus cereus, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus strains (20).
  • AnticoagulantsAnticoagulants: According to secondary sources, tormentil may affect blood coagulation. The exact mechanism of action is not well known, based on the available literature.
  • Antielastase agentsAntielastase agents: Procyanidin pentamers and hexamers extracted from tormentil exhibited greater antielastase activity than polymers of other sizes in laboratory assays (21).
  • Anti-inflammatoriesAnti-inflammatories: In patients with erosive ulcerative lichen planus of the buccal mucosa, supplementation of standard treatment with gargling with tincture of Potentilla tormentilla, together with local application of codfish oil, led to more rapid improvement than standard treatment alone (16). In vitro, a water extract of Potentilla erecta showed potent cyclooxygenase inhibition, as well as inhibition of prostaglandin biosynthesis and platelet activating factor-induced exocytosis (3).
  • AntioxidantsAntioxidants: In laboratory research, procyanidin dimers and trimers extracted from tormentil exhibited greater radical-quenching activity in regard to lipid peroxidation than polymers of other sizes, while pentamers and hexamers may be the most active against superoxide anion (21; 24). Tormentil effectively scavenged free radicals in an in vitro model and in colorectal biopsies (2).
  • AntiviralsAntivirals: In a randomized controlled trial, tormentil root extract therapy was associated with shortened rotaviral diarrhea duration and reduced need for rehydration solution in children (11).
  • Cytotoxic agentsCytotoxic agents: Potentilla erecta extracts have been shown to inhibit the growth of cultured human Raji cells at concentrations of 10 and 50mcg/mL (22).
  • Gastrointestinal agentsGastrointestinal agents: In a trial in patients with ulcerative colitis, tormentil extract treatment was associated with improvements in the clinical activity index (CAI) (10). In this same study, mild abdominal pain was reported as an adverse effect (10). In a randomized controlled trial, tormentil root extract therapy was associated with shortened rotaviral diarrhea duration and reduced need for rehydration solution in children (11).
  • Growth-promoting agentsGrowth-promoting agents: Supplementation of cell cultures with tormentil rhizome extract, together with an antibiotic (such as cefoperazone, cefuroxime, or doxycycline) and hydrocortisone, has been shown to enhance cell survival (23).
  • HepaticsHepatics: In a clinical trial of patients with active pulmonary tuberculosis (TB), an herbal extract containing tormentil (Potentilla erecta) appeared to minimize or reverse liver damage caused by standard anti-TB therapy (17).
  • HypoglycemicsHypoglycemics: According to secondary sources, tormentil may lower blood glucose. The exact mechanism of action is not well known, based on the available literature.
  • Pulmonary agentsPulmonary agents: In a clinical trial of patients with active pulmonary tuberculosis, an herbal extract containing tormentil (Potentilla erecta) showed a higher rate of healing of pulmonary infiltrations and cavities when used together with standard treatment, compared with standard treatment alone (17).

    • Tormentil/Food Interactions:

  • Insufficient available evidence.

    • Tormentil/Lab Interactions:

  • Agglutination testsAgglutination tests: Tannins isolated from tormentil have been shown to have agglutinating effects (19).
  • Blood glucoseBlood glucose: According to secondary sources, tormentil may lower blood glucose. The exact mechanism of action is not well known, based on the available literature.
  • Coagulation panelCoagulation panel: According to secondary sources, tormentil may affect blood coagulation. The exact mechanism of action is not well known, based on the available literature.
  • ElastaseElastase: Procyanidin pentamers and hexamers extracted from tormentil exhibited greater antielastase activity than polymers of other sizes in laboratory assays (21).