Trumpet satinash

Trumpet satinash/Drug Interactions:

  • AnthelminticsAnthelmintics: In vitro, betulinic acid demonstrated strong anthelmintic activity against Caenorhabditis elegans (88).
  • Anti-inflammatory agentsAnti-inflammatory agents: Based on animal research, betulinic acid, the main constituent of trumpet satinash, may suppress 12-O-tetradecanoylphorbol-13-acetate-induced inflammation on the skin (32).
  • Antimalarial agentsAntimalarial agents: Based on in vitro evidence, betulinic acid and its derivative compounds, betulonic acid, betulinic acid acetate, betulinic acid methyl ester, and betulinic acid methyl ester acetate, may exert antiplasmodial activity against wild-type and chloroquine-resistant Plasmodium falciparum parasites (33; 34; 35). In vivo, betulinic acid acetate reduced parasitemia in mice infected with Plasmodium berghei.
  • Antineoplastic agentsAntineoplastic agents: Based on in vitro and in vivo (animal) evidence, betulinic acid, the main constituent of trumpet satinash, may induce apoptosis against a variety of cancer cells (36; 37; 38; 39; 40; 41; 42; 43; 44; 45; 46; 47; 48; 49; 50; 51; 52; 53; 54; 55; 56; 57; 58; 59; 60; 61; 62; 63; 64; 14; 13; 65; 66; 67; 68; 69; 12; 70; 71; 72; 73; 74; 75; 76; 77; 78; 79; 80; 18; 17; 81; 82; 83; 84; 85).
  • Antiretroviral agentsAntiretroviral agents: Based on in vitro evidence, betulinic acid and some of its derivatives may exert anti-HIV effects (28; 27; 26; 24; 86; 1; 87).
  • Antiviral agentsAntiviral agents: Based on in vivo evidence, betulinic acid may inhibit hepatitis B virus (HBV) replication (89).
  • Fertility agentsFertility agents: Based on in vitro evidence, betulinic acid may decrease human spermatozoa motility (29).
  • Hepatotoxic agentsHepatotoxic agents: Based on in vitro research, the derivative betulin protected against ethanol-induced cytotoxicity, while both betulin and betulinic acid significantly decreased ethanol-induced production of superoxide anion (90).

    • Trumpet satinash/Herb/Supplement Interactions:

  • Anthelmintic herbs and supplementsAnthelmintic herbs and supplements: In vitro, betulinic acid demonstrated strong anthelmintic activity against Caenorhabditis elegans (88).
  • Anti-inflammatory herbsAnti-inflammatory herbs: Based on animal research, betulinic acid, the main constituent of trumpet satinash, may suppress 12-O-tetradecanoylphorbol-13-acetate-induced inflammation on the skin (32).
  • Antimalarial herbs and supplementsAntimalarial herbs and supplements: Based on in vitro evidence, betulinic acid and its derivative compounds, betulonic acid, betulinic acid acetate, betulinic acid methyl ester, and betulinic acid methyl ester acetate, may exert antiplasmodial activity against wild-type and chloroquine-resistant Plasmodium falciparum parasites (33; 34; 35). In vivo, betulinic acid acetate reduced parasitemia in mice infected with Plasmodium berghei.
  • AntineoplasticsAntineoplastics: Based on in vitro and in vivo (animal) evidence, betulinic acid, the main constituent of trumpet satinash, may induce apoptosis against a variety of cancer cells (36; 37; 38; 39; 40; 41; 42; 43; 44; 45; 46; 47; 48; 49; 50; 51; 52; 53; 54; 55; 56; 57; 58; 59; 60; 61; 62; 63; 64; 14; 13; 65; 66; 67; 68; 69; 12; 70; 71; 72; 73; 74; 75; 76; 77; 78; 79; 80; 18; 17; 81; 82; 83; 84; 85).
  • Antiretroviral herbs and supplementsAntiretroviral herbs and supplements: Based on in vitro evidence, betulinic acid and some of its derivatives may exert anti-HIV effects (28; 27; 26; 24; 86; 1; 87).
  • AntiviralsAntivirals: Based on in vivo evidence, betulinic acid may inhibit hepatitis B virus (HBV) replication (89).
  • Fertility agentsFertility agents: Based on in vitro evidence, betulinic acid may decrease human spermatozoa motility (29).
  • Hepatotoxic herbs and supplementsHepatotoxic herbs and supplements: Based on in vitro research, the derivative betulin protected against ethanol-induced cytotoxicity, while both betulin and betulinic acid significantly decreased ethanol-induced production of superoxide anion (90).

    • Trumpet satinash/Food Interactions:

  • Insufficient available evidence.

    • Trumpet satinash/Lab Interactions:

  • Blood urea nitrogenBlood urea nitrogen: In animal research, betulinic acid normalized increases in blood urea nitrogen induced by renal ischemia/reperfusion injury (91).
  • CreatinineCreatinine: In animal research, betulinic acid normalized increases in blood creatinine induced by renal ischemia/reperfusion injury (91).
  • CytokinesCytokines: In vitro, betulinic acid analogs resulted in the production of tumor necrosis factor-alpha and interleukin-1beta in vitro (92; 93).
  • MalondialdehydeMalondialdehyde: In animal research, betulinic acid decreased elevations in malondialdehyde levels induced by renal ischemia/reperfusion injury (91).
  • Sperm motilitySperm motility: Based on in vitro evidence, betulinic acid may decrease human spermatozoa motility (29).