Fungicidals

Antifungals/Nutrient Depletion:

  • MagnesiumMagnesium: According to human and animal studies, electrolyte disturbances, including low magnesium levels, may develop in a large proportion of patients receiving amphotericin B (12134234, 9177994, 2182052). According to human and animal studies, lipid-based formulations such as Abelcet? and Anphotec? may have a lesser effect than conventional formulations (2182052). This disturbance has been associated with nephrotoxicity and may necessitate discontinuing the drug and administering intravenous electrolyte replacement.
  • PotassiumPotassium: According to animal study, amphotericin B (AMP-B) may induce potassium excretion defects (7948785). Hypokalaemia may be associated with acute myeloid leukemia after fluconazole treatment in humans (2565490).