Parkinson?s Drugs

Antiparkinson Agents/Nutrient Depletion:

  • IronIron: Based on human study, iron may reduce the amount of levodopa absorbed by forming chelates with levodopa (Sinemet?) (2920496). Secondary sources cite that until further research is available, doses of levodopa and iron should be separated.
  • Niacin/Niacinamide:Niacin/Niacinamide: Based on human study, L-dopa, benserazide, and carbidopa may deplete niacin through reduced synthesis of nicotinamide coenzymes from tryptophan and increased urinary excretion of N1-methyl-nicotinamide (477187).
  • Potassium:Potassium: Based on reviews, L-dopa may increase urinary excretion of potassium, which may lead to hypokalemia (851038, 4927447).