Povidone-iodine

Iodine/Nutrient Depletion:

  • BugleweedBugleweed: Bugleweed (Lycopus virginicus, Lycopus europaeus) may reduce iodine uptake, according to secondary sources.
  • Cruciferous vegetablesCruciferous vegetables: According to review data, goitrogens, present in high levels in cassava, cabbage, broccoli, cauliflower, and other cruciferous vegetables, interfere with the uptake of iodine in the thyroid (257).
  • IronIron: According to review data, iron deficiency may exacerbate the effects of iodine deficiency (128). Goitrous children with iron deficiency anemia experienced an impaired therapeutic response to oral iodine (131).
  • LithospermumLithospermum: Ingestion of Lithospermum may lower thyroid hormone blood levels and may interact with the effects of iodine on thyroid hormone levels, according to secondary sources.
  • MetronidazoleMetronidazole: In clinical research, children with intestinal parasitic infestations treated with metronidazole experienced reduced efficacy of oral supplementation with iodized ethyl esters by interfering with its absorption (130).
  • PerchloratePerchlorate: According to review data, perchlorate inhibits the uptake of iodide into the thyroid gland (132).
  • SeleniumSelenium: According to review data, selenium deficiency may exacerbate the effects of iodine deficiency (127). However, human supplementation with selenium and iodine did not result in a synergistic action of selenium and iodine on thyroid function (254).
  • Vitamin AVitamin A: According to review data, vitamin A deficiency may exacerbate the effects of iodine deficiency and alter the response to iodine supplementation (128). Vitamin A supplementation in iodine-deficient African children decreased thyrotropin stimulation of the thyroid and reduced the goiter rate (255).
  • ZincZinc: According to a review, there is limited evidence describing interactions between iodine and zinc metabolism (256).